caa a22 4500 378862138 CHVBK 20180305123349.0 cr unu---uuuuu 161128e20030101xx s 000 0 eng 10.1351/pac200375112321 doi (NATIONALLICENCE)gruyter-10.1351/pac200375112321 Pottinger T. G. NERC Centre for Ecology and Hydrology Windermere, The Ferry House, Far Sawrey, Ambleside, Cumbria LA22 0LP, UK Interactions of endocrine-disrupting chemicals with stress responses in wildlife [Elektronische Daten] [T. G. Pottinger] The extent to which nonreproductive aspects of the endocrine system are affected by environmental contaminants is to a large extent unknown. However, an emerging body of data demonstrates that the neuroendocrine stress response is a sensitive target for disruption by a range of environmental contaminants, at a number of discrete loci. Several mechanisms are responsible for generating and sustaining the corticosteroid response to a stressor, including synthesis of the steroid, negative feedback at the pituitary and hypothalamus, and clearance via metabolism and conjugation in peripheral tissues and the liver. Laboratory and field studies provide evidence that these elements of the stress response are susceptible to interference by EAS. The functional significance to the individual of interference with this important adaptive mechanism remains to be established. © 2013 Walter de Gruyter GmbH, Berlin/Boston Pure and Applied Chemistry De Gruyter 75/11-12(2003-01-01), 2321-2333 0033-4545 75:11-12<2321 2003 75 pac https://doi.org/10.1351/pac200375112321 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200375112321 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Pottinger T. G. NERC Centre for Ecology and Hydrology Windermere, The Ferry House, Far Sawrey, Ambleside, Cumbria LA22 0LP, UK NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 75/11-12(2003-01-01), 2321-2333 0033-4545 75:11-12<2321 2003 75 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter