caa a22 4500 378862839 CHVBK 20180305123350.0 cr unu---uuuuu 161128e20031201xx s 000 0 eng 10.1524/zpch.217.12.1463.20475 doi (NATIONALLICENCE)gruyter-10.1524/zpch.217.12.1463.20475 Hydrogen Bond Mediated Association of Dinucleotide Analogs [Elektronische Daten] [Eline M. Basílio Janke, Klaus Weisz] Several dinucleotide analogs, in which two of the nucleobases adenine, thymine and uracil are connected by a hexadecamethylene linker have been synthesized and studied for their base-base interaction in a chloroform solution. Using 1H NMR spectroscopic techniques intramolecular base pair formation through hydrogen bonding is observed at ambient temperatures but found to strongly depend on the identity of paired bases. Thus, whereas cyclization through intramolecular base-base interactions predominate for adenine-(CH2)16-thymine and adenine-(CH2)16-uracil, no intramolecular adenine-adenine pairing was observed. Upon addition of acetic acid to adenine-(CH2)16-thymine, strong adenine-acetic acid interactions result in the disruption of preformed intramolecular adenine-thymine base pairs. © 2003 Oldenbourg Wissenschaftsverlag GmbH Thermodynamics & statistical physics nationallicence Laboratory techniques, experiments nationallicence Physical chemistry nationallicence Basílio Janke Eline M. aut Weisz Klaus aut Zeitschrift für Physikalische Chemie/International journal of research in physical chemistry and chemical physics Oldenbourg Wissenschaftsverlag GmbH 217/12/2003(2003-12-01), 1463-1472 0044-3336 217:12/2003<1463 2003 217 zpch https://doi.org/10.1524/zpch.217.12.1463.20475 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1524/zpch.217.12.1463.20475 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Basílio Janke Eline M. aut NATIONALLICENCE 700 1- Weisz Klaus aut NATIONALLICENCE 773 0- Zeitschrift für Physikalische Chemie/International journal of research in physical chemistry and chemical physics Oldenbourg Wissenschaftsverlag GmbH 217/12/2003(2003-12-01), 1463-1472 0044-3336 217:12/2003<1463 2003 217 zpch CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter