caa a22 4500 378866192 CHVBK 20180305123358.0 cr unu---uuuuu 161128e20030101xx s 000 0 eng 10.1351/pac200375020375 doi (NATIONALLICENCE)gruyter-10.1351/pac200375020375 Rohmer M. Université Louis Pasteur/CNRS/Institut Universitaire de France, Institut Le Bel, 4 rue Blaise Pascal, 67070 Strasbourg Cedex, France Mevalonate-independent methylerythritol phosphate pathway for isoprenoid biosynthesis. Elucidation and distribution [Elektronische Daten] [M. Rohmer] A long-overlooked metabolic pathway for isoprenoid biosynthesis, the mevalonate-independent methylerythritol phosphate (MEP) pathway, is present in many bacteria and in the chloroplasts of all phototrophic organisms. It represents an alternative to the well known mevalonate pathway, which is present in animals, fungi, plant cytoplasm, archaebacteria, and some eubacteria. This contribution summarizes key steps of its elucidation and the state-of-the-art knowledge of this biosynthetic pathway, which represents a novel target for antibacterial and antiparasitic drugs. © 2013 Walter de Gruyter GmbH, Berlin/Boston Pure and Applied Chemistry De Gruyter 75/2-3(2003-01-01), 375-388 0033-4545 75:2-3<375 2003 75 pac https://doi.org/10.1351/pac200375020375 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200375020375 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Rohmer M. Université Louis Pasteur/CNRS/Institut Universitaire de France, Institut Le Bel, 4 rue Blaise Pascal, 67070 Strasbourg Cedex, France NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 75/2-3(2003-01-01), 375-388 0033-4545 75:2-3<375 2003 75 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter