caa a22 4500 378866230 CHVBK 20180305123358.0 cr unu---uuuuu 161128e20030101xx s 000 0 eng 10.1351/pac200375020413 doi (NATIONALLICENCE)gruyter-10.1351/pac200375020413 Combination of enzymatic procedures with multicomponent condensations [Elektronische Daten] [R. Ostaszewski, D. E. Portlock, Anna Fryszkowska, Katarzyna Jeziorska] A new synthetic method based on combination of enzymatic desymmetrization of 3-phenylglutaric anhydrides with multicomponent condensation is outlined. Enzymatic monoesterification of glutaric anhydrides was performed, and the derived monoacids were used as substrates for subsequent Ugi and Passerini multicomponent condensations. Both reactions were combined as two-step, one-pot processes. The choice of solvent and enzyme type has an appreciable effect on the course of reactions. © 2013 Walter de Gruyter GmbH, Berlin/Boston Ostaszewski R. Faculty of Chemistry, Warsaw University of Technology, 00-664 Warsaw, Noakowskiego 3, Poland aut Portlock D. E. Combinatorial Chemistry Section, Procter & Gamble Pharmaceuticals, Health Care Research Center, 8700 Mason Montgomery Road, Mason, OH 45040, USA aut Fryszkowska Anna Faculty of Chemistry, Warsaw University of Technology, 00-664 Warsaw, Noakowskiego 3, Poland aut Jeziorska Katarzyna Faculty of Chemistry, Warsaw University of Technology, 00-664 Warsaw, Noakowskiego 3, Poland aut Pure and Applied Chemistry De Gruyter 75/2-3(2003-01-01), 413-419 0033-4545 75:2-3<413 2003 75 pac https://doi.org/10.1351/pac200375020413 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200375020413 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ostaszewski R. Faculty of Chemistry, Warsaw University of Technology, 00-664 Warsaw, Noakowskiego 3, Poland aut NATIONALLICENCE 700 1- Portlock D. E. Combinatorial Chemistry Section, Procter & Gamble Pharmaceuticals, Health Care Research Center, 8700 Mason Montgomery Road, Mason, OH 45040, USA aut NATIONALLICENCE 700 1- Fryszkowska Anna Faculty of Chemistry, Warsaw University of Technology, 00-664 Warsaw, Noakowskiego 3, Poland aut NATIONALLICENCE 700 1- Jeziorska Katarzyna Faculty of Chemistry, Warsaw University of Technology, 00-664 Warsaw, Noakowskiego 3, Poland aut NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 75/2-3(2003-01-01), 413-419 0033-4545 75:2-3<413 2003 75 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter