Bioactive macrolides and polyketides from marine dinoflagellates
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| 005 | 20180305123358.0 | ||
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| 008 | 161128e20030101xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1351/pac200375020337 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1351/pac200375020337 | ||
| 245 | 0 | 0 | |a Bioactive macrolides and polyketides from marine dinoflagellates |h [Elektronische Daten] |c [J. Kobayashi, K. Shimbo, Takaaki Kubota, M. Tsuda] |
| 520 | 3 | |a Absolute stereochemistry of amphidinolides G and H, potent cytotoxic 27- and 26-membered macrolides, respectively, isolated from a marine dinoflagellate Amphidinium sp., was determined by X-ray diffraction analysis, synthesis of a degradation product, and chemical interconversion. Six new macrolides, amphidinolides H2~H5, G2, G3, and W, have been isolated from a marine dinoflagellate Amphidinium sp. (strain Y-42), and the structures were elucidated by 2D NMR data and chemical means. The structure-activity relationship of amphidinolide H-type macrolides for cytotoxicity was examined. The biosynthetic origins of amphidinolides B, C, H, J, T1, and W were investigated on the basis of 13C NMR data of 13C-enriched samples obtained by feeding experiments with [1-13C], [2-13C], and [1,2-13C2] sodium acetates in cultures of the dinoflagellates. Five novel long-chain polyhydroxyl compounds, colopsinols A~E, were obtained from the Amphidinium sp. (strain Y-5). | |
| 540 | |a © 2013 Walter de Gruyter GmbH, Berlin/Boston | ||
| 700 | 1 | |a Kobayashi |D J. |u Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-012, Japan |4 aut | |
| 700 | 1 | |a Shimbo |D K. |u Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-012, Japan |4 aut | |
| 700 | 1 | |a Kubota |D Takaaki |u Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-012, Japan |4 aut | |
| 700 | 1 | |a Tsuda |D M. |u Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-012, Japan |4 aut | |
| 773 | 0 | |t Pure and Applied Chemistry |d De Gruyter |g 75/2-3(2003-01-01), 337-342 |x 0033-4545 |q 75:2-3<337 |1 2003 |2 75 |o pac | |
| 856 | 4 | 0 | |u https://doi.org/10.1351/pac200375020337 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1351/pac200375020337 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kobayashi |D J. |u Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-012, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shimbo |D K. |u Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-012, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kubota |D Takaaki |u Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-012, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tsuda |D M. |u Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-012, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Pure and Applied Chemistry |d De Gruyter |g 75/2-3(2003-01-01), 337-342 |x 0033-4545 |q 75:2-3<337 |1 2003 |2 75 |o pac | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||