caa a22 4500 378866265 CHVBK 20180305123358.0 cr unu---uuuuu 161128e20030101xx s 000 0 eng 10.1351/pac200375020337 doi (NATIONALLICENCE)gruyter-10.1351/pac200375020337 Bioactive macrolides and polyketides from marine dinoflagellates [Elektronische Daten] [J. Kobayashi, K. Shimbo, Takaaki Kubota, M. Tsuda] Absolute stereochemistry of amphidinolides G and H, potent cytotoxic 27- and 26-membered macrolides, respectively, isolated from a marine dinoflagellate Amphidinium sp., was determined by X-ray diffraction analysis, synthesis of a degradation product, and chemical interconversion. Six new macrolides, amphidinolides H2~H5, G2, G3, and W, have been isolated from a marine dinoflagellate Amphidinium sp. (strain Y-42), and the structures were elucidated by 2D NMR data and chemical means. The structure-activity relationship of amphidinolide H-type macrolides for cytotoxicity was examined. The biosynthetic origins of amphidinolides B, C, H, J, T1, and W were investigated on the basis of 13C NMR data of 13C-enriched samples obtained by feeding experiments with [1-13C], [2-13C], and [1,2-13C2] sodium acetates in cultures of the dinoflagellates. Five novel long-chain polyhydroxyl compounds, colopsinols A~E, were obtained from the Amphidinium sp. (strain Y-5). © 2013 Walter de Gruyter GmbH, Berlin/Boston Kobayashi J. Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-012, Japan aut Shimbo K. Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-012, Japan aut Kubota Takaaki Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-012, Japan aut Tsuda M. Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-012, Japan aut Pure and Applied Chemistry De Gruyter 75/2-3(2003-01-01), 337-342 0033-4545 75:2-3<337 2003 75 pac https://doi.org/10.1351/pac200375020337 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200375020337 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kobayashi J. Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-012, Japan aut NATIONALLICENCE 700 1- Shimbo K. Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-012, Japan aut NATIONALLICENCE 700 1- Kubota Takaaki Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-012, Japan aut NATIONALLICENCE 700 1- Tsuda M. Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-012, Japan aut NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 75/2-3(2003-01-01), 337-342 0033-4545 75:2-3<337 2003 75 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter