Are Results of Fibrinogen Measurements Transferable?

Verfasser / Beitragende:
[Anders Kallner, Nils Egberg, Anna Yu, Rumjana Merzoug-Djilali, Inger Blomberg, Gun Jörneskog, Margareta Blombäck]
Ort, Verlag, Jahr:
2003
Enthalten in:
Clinical Chemistry and Laboratory Medicine, 41/6(2003-06-17), 804-808
Format:
Artikel (online)
ID: 37886730X
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024 7 0 |a 10.1515/CCLM.2003.122  |2 doi 
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245 0 0 |a Are Results of Fibrinogen Measurements Transferable?  |h [Elektronische Daten]  |c [Anders Kallner, Nils Egberg, Anna Yu, Rumjana Merzoug-Djilali, Inger Blomberg, Gun Jörneskog, Margareta Blombäck] 
520 3 |a Fibrinogen concentration is routinely measured by several methods and the results may influence diagnostic and treatment strategies. It is therefore necessary that results are compatible and transferable between laboratories. In the present study, it is shown that commonly used immuno-nephelometric methods, a commercial variant of the Clauss clotting rate method, and the classical syneresis method, do not differ significantly using patient material, in the interval 2-12 g/l. A research ELISA method that measures intact fibrinogen is not linearly correlated to the syneresis method. The commutability of available calibrators and reference materials (including the WHO 2nd IS) was only 50-80% except for one of the calibrators for which the virtual concentration coincided with that obtained by the 
540 |a Copyright © 2003 by Walter de Gruyter GmbH & Co. KG 
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