caa a22 4500 378867326 CHVBK 20180305123401.0 cr unu---uuuuu 161128e20030617xx s 000 0 eng 10.1515/CCLM.2003.124 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.124 Association between Increased Serum Cholesterol and Signs of Depressive Mood [Elektronische Daten] [Maximilian Ledochowski, Christian Murr, Barbara Sperner-Unterweger, Gabriele Neurauter, Dietmar Fuchs] Hypercholesterolemia is associated with an increased risk of atherosclerosis and coronary heart disease. Therefore, therapeutic lowering of cholesterol is an important preventive measure of cardiac morbidity and death. As one side effect, cholesterol-lowering drugs appear to increase the mortality due to suicides or violence, and low lipid concentrations were found to be associated with trait measures of depression. We compared serum cholesterol concentrations and the Beck Depression Rating Scale (Beck's score) in 604 otherwise healthy outpatients who visited the physician's office for a medical health check-up; 65.4% of individuals presented with serum cholesterol concentrations ≥5.2 mmol/l (>200 mg/dl) and 5.3% had elevated Beck's score (>19), indicative for depression. Beck's score was higher in patients with cholesterol concentrations above the 75th percentile (=6.2 mmol/l; U = 31221, p<0.02, Mann-Whitney U-test), and Beck's score correlated with cholesterol concentrations and with age. Thus, in contrast to the widely accepted view, in our study, higher cholesterol concentrations were associated with signs of depressive mood. Hypercholesterolemia may not necessarily increase the risk of depressive mood, conversely, increased intake of fat and carbohydrates by individuals with depressive mood may increase cholesterol levels. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Ledochowski Maximilian aut Murr Christian aut Sperner-Unterweger Barbara aut Neurauter Gabriele aut Fuchs Dietmar aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/6(2003-06-17), 821-824 1434-6621 41:6<821 2003 41 cclm https://doi.org/10.1515/CCLM.2003.124 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.124 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ledochowski Maximilian aut NATIONALLICENCE 700 1- Murr Christian aut NATIONALLICENCE 700 1- Sperner-Unterweger Barbara aut NATIONALLICENCE 700 1- Neurauter Gabriele aut NATIONALLICENCE 700 1- Fuchs Dietmar aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/6(2003-06-17), 821-824 1434-6621 41:6<821 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter