caa a22 4500 378867334 CHVBK 20180305123401.0 cr unu---uuuuu 161128e20030617xx s 000 0 eng 10.1515/CCLM.2003.117 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.117 Is Capillary Electrophoresis a Method of Choice for Systematic Toxicological Analysis? [Elektronische Daten] [Carolien M. Boone, Kees Ensing] This review presents an overview of current research on the use of capillary electrophoretic techniques for the analysis of drugs in biological matrices. The discussion focuses on the applicability of the methods for the identification of unknown toxic compounds, which is defined as systematic toxicological analysis (STA). The aim is to establish whether or not capillary electrophoresis (CE), in one or more of its separation modes, is a method of choice in systematic toxicological analysis. To answer this question, various aspects are discussed, including sample work-up, separation modes, detection techniques, electrophoretic concentration, and identification by database retrieval. Several ways to improve the poor reproducibility and sensitivity are discussed. This leads to the conclusion that CE can be comparable to HPLC in those respects, while it is more favorable in speed, efficiency, and cost. Thus, we conclude that CE is a method of choice for STA, keeping in mind that every method has its limitations and that a combination of several non-correlated methods is always required for the identification of unknown compounds. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Boone Carolien M. aut Ensing Kees aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/6(2003-06-17), 773-781 1434-6621 41:6<773 2003 41 cclm https://doi.org/10.1515/CCLM.2003.117 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.117 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Boone Carolien M. aut NATIONALLICENCE 700 1- Ensing Kees aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/6(2003-06-17), 773-781 1434-6621 41:6<773 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter