caa a22 4500 378867571 CHVBK 20180305123401.0 cr unu---uuuuu 161128e20030401xx s 000 0 eng 10.1524/ract.91.4.241.19967 doi (NATIONALLICENCE)gruyter-10.1524/ract.91.4.241.19967 Radiosynthesis of 3-{[4-(4-[18F]fluorobenzyl)]piperazin-1-yl}methyl-1H-pyrrolo[2,3-b]pyridine: A potential dopamine D4 receptor imaging agent [Elektronische Daten] [Tian Hai-Bin, Yin Duan-Zhi, Li Jun-Ling, Zhang Lan, Zhang Cun-Fu, Wang Yong-Xian, Zhou Wei] The dopamine D4 receptor (D4R) is expressed in low density in various extrastriatal brain regions. This receptor subtype is discussed in relation to the pathophysiology and treatment of schizophrenia but to date no selective positron emission tomography (PET) ligand is available to study its distribution in vivo . The 7-azaindole derivative 3-{[4-(4-iodophenyl)piperazin-1-yl]-methyl}-1H-pyrrolo[2,3-b]pyridine (L-750,667) is a novel, high-affinity (Ki=0.51nM) and selective D4R ligand. L-750,667 analogue 3-{[4-(4-[18F]fluorobenzyl)]piperazin-1-yl}methyl-1H-pyrrolo[2,3-b]-pyridine was prepared by reacting 3-(piperazin-1-yl)-methyl-1H-pyrrolo[2,3-b]pyridine with 4-[18F]fluorobenzaldehyde, which was labeled with no carrier added [18F]fluoride. The radiochemical yield of 3-{[4-(4-[18F]fluorobenzyl)]piperazin-1-yl}methyl-1H-pyrrolo[2,3-b]pyridine was 12.0 at end of synthesis (EOS), and the synthesis time was 73min. The labeled benzaldehydes may be useful precursors for the radiosyntheses of other complex radiotracers for PET. © 2003 Oldenbourg Wissenschaftsverlag GmbH Laboratory techniques, experiments nationallicence Analytical chemistry nationallicence Inorganic chemistry nationallicence Hai-Bin Tian aut Duan-Zhi Yin aut Jun-Ling Li aut Lan Zhang aut Cun-Fu Zhang aut Yong-Xian Wang aut Wei Zhou aut Radiochimica Acta/International journal for chemical aspects of nuclear science and technology Oldenbourg Wissenschaftsverlag GmbH 91/4/2003(2003-04-01), 241-245 0033-8230 91:4/2003<241 2003 91 ract https://doi.org/10.1524/ract.91.4.241.19967 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1524/ract.91.4.241.19967 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hai-Bin Tian aut NATIONALLICENCE 700 1- Duan-Zhi Yin aut NATIONALLICENCE 700 1- Jun-Ling Li aut NATIONALLICENCE 700 1- Lan Zhang aut NATIONALLICENCE 700 1- Cun-Fu Zhang aut NATIONALLICENCE 700 1- Yong-Xian Wang aut NATIONALLICENCE 700 1- Wei Zhou aut NATIONALLICENCE 773 0- Radiochimica Acta/International journal for chemical aspects of nuclear science and technology Oldenbourg Wissenschaftsverlag GmbH 91/4/2003(2003-04-01), 241-245 0033-8230 91:4/2003<241 2003 91 ract CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter