caa a22 4500 378869574 CHVBK 20180305123406.0 cr unu---uuuuu 161128e20030127xx s 000 0 eng 10.1515/CCLM.2003.005 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.005 3-Nitrotyrosine in Atherosclerotic Blood Vessels [Elektronische Daten] [Nehir Sucu, Ali ünlü, Lülüfer Tamer, Barlas Aytacoglu, Bahadir Ercan, Murat Dikmengil, Ugur Atik] The effect of peroxynitrite on the development of atherosclerosis is one of the major foci of recent studies. Here, the cytotoxic effect of peroxynitrite was investigated by quantitatively measuring nitrated tyrosine, 3-nitrotyrosine (3-NT) levels in atherosclerotic blood vessels. Atherosclerotic vessels were obtained from the patients who underwent either coronary artery or peripheric artery bypass surgery. Internal thoracic arteries of the patients were treated as non-atherosclerotic control vessels. 3-NT was measured by reverse-phase HPLC and plasma nitrite-nitrate levels were measured by spectrophotometry. 3-NT levels were significantly elevated in atherosclerotic vessels (46.6±23.3 nmol/mg protein, n = 15; p < 0.001) in comparison to control vessels (15.8±2.5 nmol/mg protein, n = 10). Vessel 3-NT correlated weakly with plasma nitrate levels (r = 0.38). Thus, atherosclerotic arteries have higher 3-NT levels than non-atherosclerotic blood vessels. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Sucu Nehir aut ünlü Ali aut Tamer Lülüfer aut Aytacoglu Barlas aut Ercan Bahadir aut Dikmengil Murat aut Atik Ugur aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/1(2003-01-27), 23-25 1434-6621 41:1<23 2003 41 cclm https://doi.org/10.1515/CCLM.2003.005 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.005 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sucu Nehir aut NATIONALLICENCE 700 1- ünlü Ali aut NATIONALLICENCE 700 1- Tamer Lülüfer aut NATIONALLICENCE 700 1- Aytacoglu Barlas aut NATIONALLICENCE 700 1- Ercan Bahadir aut NATIONALLICENCE 700 1- Dikmengil Murat aut NATIONALLICENCE 700 1- Atik Ugur aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/1(2003-01-27), 23-25 1434-6621 41:1<23 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter