A New Modification of the Chiron ACSAssay for Total Prostate-Specific Antigen AchievesEquimolar Response Characteristics andImproves the Detection of ProstateCancer
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| 024 | 7 | 0 | |a 10.1515/CCLM.2003.016 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.016 | ||
| 245 | 0 | 2 | |a A New Modification of the Chiron ACSAssay for Total Prostate-Specific Antigen AchievesEquimolar Response Characteristics andImproves the Detection of ProstateCancer |h [Elektronische Daten] |c [Frank Oberpenning, Christoph Weining, Burkhard Brandt, Gabriela De Angelis, Achim Heinecke, Michael Hamm, Petra Stieber, Lothar Hertle, Hans-Peter Schmid, Axel Semjonow] |
| 520 | 3 | |a Nonequimolar-response assays for prostate-specific antigen (PSA) are criticized for overestimating total PSA in some men without prostate cancer (PCA), and underestimating total PSA in some men with PCA. We recently studied three nonequimolar-response PSA assays that had undergone modifications. While two of the studied assays achieved equimolar-response characteristics with improved areas under receiver operating characteristic (ROC) curves (AUC), the modification of the Chiron ACS PSA assay (ACS PSA2, Chiron) failed to achieve this. Recently, the ACS assay underwent another modification (ACS PSA, Bayer), which we investigated. Sera from 305 men (155 without and 150 with PCA, PSA ≥2 and ≤30 μg/l, Tandem-E) were measured using both modifications of the ACS assay and equimolar-response reference methods (Tandem-R free and Tandem- E, Hybritech). Molar response relative to the reference method and clinical performance (comparison of AUCs) between the previous and new ACS assay modifications were studied. The new modification of the ACS assay (ACS PSA, Bayer) achieved equimolar-response characteristics but reported lower values (average 10%) than the Tandem-E assay. Compared to the previous modification (ACS PSA2, Chiron), a 3% improvement in AUC (p = 0.01) was found. Using results of the redesigned equimolar-response assay (ACS PSA, Bayer), we calculated that 6 of 155 men without PCA in this sample set could be spared unnecessary biopsy compared with the previous nonequimolar-response assay (ACS PSA2, Chiron) without missing additional PCA (90% sensitivity). These data provide additional evidence for clinical advantages of equimolar-response over nonequimolar-response PSA assay formats. | |
| 540 | |a Copyright © 2003 by Walter de Gruyter GmbH & Co. KG | ||
| 690 | 7 | |a Medical equipment & techniques |2 nationallicence | |
| 690 | 7 | |a Medical diagnosis |2 nationallicence | |
| 690 | 7 | |a Diseases & disorders |2 nationallicence | |
| 700 | 1 | |a Oberpenning |D Frank |4 aut | |
| 700 | 1 | |a Weining |D Christoph |4 aut | |
| 700 | 1 | |a Brandt |D Burkhard |4 aut | |
| 700 | 1 | |a De Angelis |D Gabriela |4 aut | |
| 700 | 1 | |a Heinecke |D Achim |4 aut | |
| 700 | 1 | |a Hamm |D Michael |4 aut | |
| 700 | 1 | |a Stieber |D Petra |4 aut | |
| 700 | 1 | |a Hertle |D Lothar |4 aut | |
| 700 | 1 | |a Schmid |D Hans-Peter |4 aut | |
| 700 | 1 | |a Semjonow |D Axel |4 aut | |
| 773 | 0 | |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 41/1(2003-01-27), 90-94 |x 1434-6621 |q 41:1<90 |1 2003 |2 41 |o cclm | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/CCLM.2003.016 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/CCLM.2003.016 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Oberpenning |D Frank |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Weining |D Christoph |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Brandt |D Burkhard |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a De Angelis |D Gabriela |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Heinecke |D Achim |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hamm |D Michael |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Stieber |D Petra |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hertle |D Lothar |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Schmid |D Hans-Peter |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Semjonow |D Axel |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 41/1(2003-01-27), 90-94 |x 1434-6621 |q 41:1<90 |1 2003 |2 41 |o cclm | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||