Semen Polymorphonuclear Neutrophil LeukocyteElastase as a Diagnostic and Prognostic Marker ofGenital Tract Inflammation - A Review
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| 024 | 7 | 0 | |a 10.1515/CCLM.2003.002 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.002 | ||
| 245 | 0 | 0 | |a Semen Polymorphonuclear Neutrophil LeukocyteElastase as a Diagnostic and Prognostic Marker ofGenital Tract Inflammation - A Review |h [Elektronische Daten] |c [Branko Zorn, Alenka Sešek-Briški, Joško Osredkar, Helena Meden-Vrtovec] |
| 520 | 3 | |a Elastase is a protease released by polymorphonuclear neutrophils (PMN) during the inflammatory process. Since 1987, seminal elastase-inhibitor complex (Ela/α1-PI) has been proposed as a marker of male silent genital tract inflammation. Measured by immunoassay in seminal plasma, Ela/α1-PI at a cut-off level of ≥230 μg/l, is useful in the detection of genital tract inflammation. The prevalence of increased seminal Ela/α1-PI in infertile men is significantly higher than that observed in fertile men. The Ela/α1-PI level is positively correlated with other seminal fluid markers of male genital tract inflammation: reduced semen volume, citric acid, fructose, and increased albumin, complement component C3, caeruloplasmin, immunoglobulins IgG and IgA, and cytokines interleukins-8 and -6. A higher seminal Ela/α1-PI level is significantly associated with tubal damage in female partners. After antibiotic therapy, a decrease of Ela/α1-PI level is observed. The presence of tubal damage in the partner may negatively affect the response to antibiotic treatment. A higher seminal Ela/α1-PI is associated with lower percentage of sperm with single-stranded deoxyribonucleic acid (DNA) and better fertilization rate in in vitro fertilization. Besides infertility, the determination of Ela/α1-PI is useful to confirm the presence of prostate and other male accessory gland bacterial inflammation. Screening for PMN Ela/α1-PI is easy to perform and reproducible and is a reliable quantitative test for diagnosis and prognosis of silent genital tract inflammation of couples. Moreover, sequential determinations allow the follow-up of inflammation during and after therapy. | |
| 540 | |a Copyright © 2003 by Walter de Gruyter GmbH & Co. KG | ||
| 690 | 7 | |a Medical equipment & techniques |2 nationallicence | |
| 690 | 7 | |a Medical diagnosis |2 nationallicence | |
| 690 | 7 | |a Diseases & disorders |2 nationallicence | |
| 700 | 1 | |a Zorn |D Branko |4 aut | |
| 700 | 1 | |a Sešek-Briški |D Alenka |4 aut | |
| 700 | 1 | |a Osredkar |D Joško |4 aut | |
| 700 | 1 | |a Meden-Vrtovec |D Helena |4 aut | |
| 773 | 0 | |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 41/1(2003-01-27), 2-12 |x 1434-6621 |q 41:1<2 |1 2003 |2 41 |o cclm | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/CCLM.2003.002 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/CCLM.2003.002 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zorn |D Branko |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sešek-Briški |D Alenka |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Osredkar |D Joško |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Meden-Vrtovec |D Helena |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 41/1(2003-01-27), 2-12 |x 1434-6621 |q 41:1<2 |1 2003 |2 41 |o cclm | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||