Urinary Plasma Protein Patterns in AcuteProstatitis
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| 024 | 7 | 0 | |a 10.1515/CCLM.2003.014 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.014 | ||
| 245 | 0 | 0 | |a Urinary Plasma Protein Patterns in AcuteProstatitis |h [Elektronische Daten] |c [Karel Everaert, Joris Delanghe, Marc Vanderkelen, Kristof Cornelis, Stefaan De Wachter, Annick Viaene, Eddy De Ruyck, Bart Clarysse, Willem Oosterlinck] |
| 520 | 3 | |a We evaluated the diagnostic utility of urinary α1-microglobulin, α2-macroglobulin and albumin in the diagnosis of acute prostatitis. We studied 133 men (43±17 years) with, and a reference population (n=36, 41±16 years) without, urinary tract infection. Prostatectomy samples were used to study the potential interference between prostatic proteins and protein analysis. Urinary α2-macroglobulin/albumin ratio was significantly lower in prostatitis compared to the reference population, cystitis or acute pyelonephritis (p <0.0001). Low α2-macroglobulin concentrations in prostatitis are due to inhibition (p = 0.0001) of the immune reaction between α2-macroglobulin in presence of polyclonal rabbit antibodies (used for immunonephelometry) by soluble prostatic proteins (± 60 kDa) which appear in urine in acute prostatitis. The urinary α1-microglobulin/creatinine ratio diagnoses acute pyelonephritis (sensitivity 100% and specificity 87%) and the urinary α2-macroglobulin/albumin ratio diagnoses acute prostatitis (sensitivity 100% and specificity of 90%). Stepwise multinomial logistic regression analysis reveals that urinary α1-microglobulin, α2-macroglobulin, albumin and creatinine provide optimal differentiation between acute pyelonephritis and acute prostatitis (pseudo R2=0.83; Loglikelihood −30.55, p <0.000001). In conclusion, the combination of hematuria and absence of urinary alpha-2-macroglobulin is diagnostic for acute prostatitis. Even without hematuria, α2-macroglobulin remains lower compared to patients without prostatitis. | |
| 540 | |a Copyright © 2003 by Walter de Gruyter GmbH & Co. KG | ||
| 690 | 7 | |a Medical equipment & techniques |2 nationallicence | |
| 690 | 7 | |a Medical diagnosis |2 nationallicence | |
| 690 | 7 | |a Diseases & disorders |2 nationallicence | |
| 700 | 1 | |a Everaert |D Karel |4 aut | |
| 700 | 1 | |a Delanghe |D Joris |4 aut | |
| 700 | 1 | |a Vanderkelen |D Marc |4 aut | |
| 700 | 1 | |a Cornelis |D Kristof |4 aut | |
| 700 | 1 | |a De Wachter |D Stefaan |4 aut | |
| 700 | 1 | |a Viaene |D Annick |4 aut | |
| 700 | 1 | |a De Ruyck |D Eddy |4 aut | |
| 700 | 1 | |a Clarysse |D Bart |4 aut | |
| 700 | 1 | |a Oosterlinck |D Willem |4 aut | |
| 773 | 0 | |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 41/1(2003-01-27), 79-84 |x 1434-6621 |q 41:1<79 |1 2003 |2 41 |o cclm | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/CCLM.2003.014 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/CCLM.2003.014 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Everaert |D Karel |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Delanghe |D Joris |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Vanderkelen |D Marc |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cornelis |D Kristof |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a De Wachter |D Stefaan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Viaene |D Annick |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a De Ruyck |D Eddy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Clarysse |D Bart |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Oosterlinck |D Willem |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 41/1(2003-01-27), 79-84 |x 1434-6621 |q 41:1<79 |1 2003 |2 41 |o cclm | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||