caa a22 4500 378874233 CHVBK 20180305123416.0 cr unu---uuuuu 161128e20030220xx s 000 0 eng 10.1515/BC.2003.021 doi (NATIONALLICENCE)gruyter-10.1515/BC.2003.021 Thrombin Signaling in the Brain: The Role ofProtease-Activated Receptors [Elektronische Daten] [H. Wang, G. Reiser] Signaling by the protease thrombin has started to be appreciated in cell biology, especially since the gene for proteaseactivated receptor-1 (PAR-1) has been cloned. Apart from the central role of thrombin in blood coagulation and wound healing, thrombin also regulates cellular functions in a large variety of cells through PAR-1, PAR-3 and PAR-4. Receptors are activated by a proteolytic cleavage mechanism via G protein-coupled signaling pathways. Accumulating evidence shows that thrombin changes the morphology of neurons and astrocytes, induces glial cell proliferation, and even exerts, depending on the concentration applied, either cytoprotective or cytotoxic effects on neural cells. These effects may be mediated, through either distinct or overlapping signal transduction cascades, by activation of PARs. This review focuses on the underlying signaling events initiated by thrombin in neuronal and glial cells, to summarize our understanding of the intracellular signaling machinery linking thrombin receptors to their potential physiological and pathological functions in the CNS. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Biochemistry nationallicence Molecular biology nationallicence Cellular biology nationallicence Wang H. aut Reiser G. aut Biological Chemistry Walter de Gruyter 384/2(2003-02-20), 193-202 1431-6730 384:2<193 2003 384 bchm https://doi.org/10.1515/BC.2003.021 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/BC.2003.021 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang H. aut NATIONALLICENCE 700 1- Reiser G. aut NATIONALLICENCE 773 0- Biological Chemistry Walter de Gruyter 384/2(2003-02-20), 193-202 1431-6730 384:2<193 2003 384 bchm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter