caa a22 4500 37887599X CHVBK 20180305123420.0 cr unu---uuuuu 161128e20030515xx s 000 0 eng 10.1515/CCLM.2003.100 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.100 Follicular Fluid Renin Concentration inPatients with Polycystic Ovaries Treated withGonadotrophins in an in vitro FertilisationProgramme [Elektronische Daten] [Eda Vrtačnik-Bokal, Helena Meden-Vrtovec, Joško Osredkar, Ivan Verdenik] The initial hypothesis was that the follicular fluid prorenin concentration was higher in women with polycystic ovaries (PCO) compared to normally cycling women stimulated by gonadotrophins. In a controlled prospective study, 47 women undergoing in vitro fertilisation (IVF) were enrolled: 20 women with PCO represented the study group and 27 normally cycling women the control group. Plasma prorenin, active renin, serum oestradiol, and androstenedione concentrations were measured on the day of human chorionic gonadotrophin (HCG) administration and 36 hours after HCG administration. Follicular fluid prorenin, active renin, oestradiol, and androstenedione concentrations from the dominant follicle and pooled follicles were measured 36 hours after HCG administration. Plasma prorenin concentration 36 hours after HCG administration was significantly higher in the PCO group (1867 μU/l; range 1137-3162 μU/l) than in controls (860 μU/l; range 433-1763 μU/l) (p = 0.007). The follicular fluid prorenin concentration in the dominant follicle and in the pooled follicles was lower in the PCO group (20190 μU/l; range 11130-25955 μU/l) than in controls (46930 μU/l; range 20671-66171 μU/l) (p = 0.003). We conclude that plasma prorenin concentrations in gonadotrophin-stimulated PCO cycles are augmented due to numerous follicles. Lower follicular fluid prorenin concentrations in women with PCO show that the synthesis of prorenin in theca cells starts later after HCG administration than in normally cycling women. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Vrtačnik-Bokal Eda aut Meden-Vrtovec Helena aut Osredkar Joško aut Verdenik Ivan aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/5(2003-05-15), 663-667 1434-6621 41:5<663 2003 41 cclm https://doi.org/10.1515/CCLM.2003.100 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.100 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vrtačnik-Bokal Eda aut NATIONALLICENCE 700 1- Meden-Vrtovec Helena aut NATIONALLICENCE 700 1- Osredkar Joško aut NATIONALLICENCE 700 1- Verdenik Ivan aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/5(2003-05-15), 663-667 1434-6621 41:5<663 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter