caa a22 4500 378876058 CHVBK 20180305123420.0 cr unu---uuuuu 161128e20030515xx s 000 0 eng 10.1515/CCLM.2003.098 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.098 Hematopoietic Growth Factors in ColorectalCancer Patients [Elektronische Daten] [Barbara Mroczko, Maciej Szmitkowski, Bogna Okulczyk] Hematopoietic growth factors (HGFs) are involved in the regulation of growth and spread of cancer. Therefore, in the present study, we have investigated in colorectal cancer patients the serum levels of selected HGFs, such as stem cell factor (SCF), interleukin 3 (IL-3), granulocyte-macrophage-colony stimulating factor (GM-CSF), and M-CSF in relation to controls and to the classical tumor markers, such as carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) in colorectal cancer. Additionally, we have compared the serum levels of cytokines with tumor site and stage and other clinical characteristics such as age and sex. We also defined the receiver-operating characteristics (ROC) curve for HGFs and classical tumor markers. The tested cytokines were measured in 70 patients with colorectal cancer and in 40 healthy subjects. HGFs were determined using enzyme-linked immunosorbent assay (ELISA). CEA and CA 19-9 were measured by microparticle enzyme immunoassay. There were significant differences in the levels of circulating SCF, IL-3, M-CSF, GM-CSF, and CEA and CA 19-9 in the colorectal cancer patients compared to the control group. The levels of M-CSF and CEA were significantly higher in patients with a more advanced tumor stage. The significant positive correlation was observed between the CEA and CA 19-9 concentrations. The M-CSF serum levels correlated positively with the tested tumor markers. The M-CSF area under the ROC curve was the largest. These results suggest that M-CSF is, among the tested HGFs, the best candidate for a colorectal cancer tumor marker. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Mroczko Barbara aut Szmitkowski Maciej aut Okulczyk Bogna aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/5(2003-05-15), 646-651 1434-6621 41:5<646 2003 41 cclm https://doi.org/10.1515/CCLM.2003.098 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.098 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mroczko Barbara aut NATIONALLICENCE 700 1- Szmitkowski Maciej aut NATIONALLICENCE 700 1- Okulczyk Bogna aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/5(2003-05-15), 646-651 1434-6621 41:5<646 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter