Pentanucleotide TTTTA and G/A -914 DNA Polymorphisms in Apolipoprotein(a) Promoter: Genotyping by Single-Tube PCR

Verfasser / Beitragende:
[Maja Živković, Aleksandra Stanković, Dragan Alavantić]
Ort, Verlag, Jahr:
2003
Enthalten in:
Clinical Chemistry and Laboratory Medicine, 41/5(2003-05-15), 632-633
Format:
Artikel (online)
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024 7 0 |a 10.1515/CCLM.2003.095  |2 doi 
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245 0 0 |a Pentanucleotide TTTTA and G/A -914 DNA Polymorphisms in Apolipoprotein(a) Promoter: Genotyping by Single-Tube PCR  |h [Elektronische Daten]  |c [Maja Živković, Aleksandra Stanković, Dragan Alavantić] 
520 3 |a It is known that pentanucleotide repeat polymorphism, consisting of varying number of (TTTTA) repeats in a promoter, is associated with plasma lipoprotein(a) levels. G/A −914 base substitution has also been correlated with pentanucleotide repeat polymorphism in individuals with high and low lipoprotein(a) levels. To facilitate future analysis of these polymorphisms we have developed a quick and reliable assay for the detection of both polymorphisms in a single polymerase chain reaction. 
540 |a Copyright © 2003 by Walter de Gruyter GmbH & Co. KG 
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