caa a22 4500 378876112 CHVBK 20180305123421.0 cr unu---uuuuu 161128e20030515xx s 000 0 eng 10.1515/CCLM.2003.103 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.103 Folate and Cobalamin Levels as Determinants ofPlasma Homocysteine in Different Age Groups ofHealthy Controls and Psychogeriatric Patients [Elektronische Daten] [Karin Nilsson, Lars Gustafson, Björn Hultberg] Homocysteine (Hcy) is the demethylated derivate of methionine and can be metabolized by two pathways. It is either catabolized by the transulfuration pathway to cysteine or remethylated to methionine mainly by the folate- and cobalamin-dependent enzyme methionine synthase. Previous findings suggest that folate is the most important vitamin determinant of plasma total homocysteine (tHcy) concentration but also that the relation between plasma tHcy levels and levels of cobalamin and folate in the circulation might differ in different populations. In the present study, we have analyzed these parameters in different age groups of healthy subjects and psychogeriatric patients, who are known to have increased plasma tHcy. The present study shows that serum cobalamin concentration is a more important determinant of plasma tHcy concentration than blood folate concentration in the age groups <65 years in both psychogeriatric patients and control subjects, whereas with increasing age blood folate concentration becomes the most important vitamin determinant. The findings of increased plasma tHcy with folate being the main vitamin determinant in the oldest age groups of patients and controls, suggest that tissue levels of folate in elderly subjects are too low and that vitamin supplementation should be given. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Nilsson Karin aut Gustafson Lars aut Hultberg Björn aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/5(2003-05-15), 681-685 1434-6621 41:5<681 2003 41 cclm https://doi.org/10.1515/CCLM.2003.103 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.103 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nilsson Karin aut NATIONALLICENCE 700 1- Gustafson Lars aut NATIONALLICENCE 700 1- Hultberg Björn aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/5(2003-05-15), 681-685 1434-6621 41:5<681 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter