caa a22 4500 378879111 CHVBK 20180305123427.0 cr unu---uuuuu 161128e20030721xx s 000 0 eng 10.1515/CCLM.2003.129 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.129 Tryptophan Metabolites and Brain Disorders [Elektronische Daten] [Trevor W. Stone, Gillian M. Mackay, Caroline M. Forrest, Catherine J. Clark, L. Gail Darlington] Tryptophan is metabolised primarily along the kynurenine pathway, of which two components are now known to have marked effects on neurons in the central nervous system. Quinolinic acid is an agonist at the population of glutamate receptors which are sensitive to N-methyl-D-aspartate (NMDA), and kynurenic acid is an antagonist at several glutamate receptors. Consequently quinolinic acid can act as a neurotoxin while kynurenic acid is neuroprotectant. A third kynurenine, 3-hydroxykynurenine, can generate free radicals and contribute to, or exacerbate, neuronal damage. Changes in the absolute or relative concentrations of these kynurenines have been implicated in a variety of central nervous system disorders such as the AIDS-dementia complex and Huntington's disease, raising the possibility that interference with their actions or synthesis could lead to new forms of pharmacotherapy for these conditions. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Stone Trevor W. aut Mackay Gillian M. aut Forrest Caroline M. aut Clark Catherine J. aut Darlington L. Gail aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/7(2003-07-21), 852-859 1434-6621 41:7<852 2003 41 cclm https://doi.org/10.1515/CCLM.2003.129 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.129 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stone Trevor W. aut NATIONALLICENCE 700 1- Mackay Gillian M. aut NATIONALLICENCE 700 1- Forrest Caroline M. aut NATIONALLICENCE 700 1- Clark Catherine J. aut NATIONALLICENCE 700 1- Darlington L. Gail aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/7(2003-07-21), 852-859 1434-6621 41:7<852 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter