Determination of Itraconazole and Hydroxyitraconazole in Plasma by Use of LiquidChromatography-Tandem Mass Spectrometrywith On-line Solid-Phase Extraction
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| 024 | 7 | 0 | |a 10.1515/CCLM.2003.139 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.139 | ||
| 245 | 0 | 0 | |a Determination of Itraconazole and Hydroxyitraconazole in Plasma by Use of LiquidChromatography-Tandem Mass Spectrometrywith On-line Solid-Phase Extraction |h [Elektronische Daten] |c [Michael Vogeser, Ute Spöhrer, Xaver Schiel] |
| 520 | 3 | |a In this paper a method for the simultaneous quantification of the anti-fungal drug itraconazole and its co-active metabolite hydroxyitraconazole in plasma employing liquid chromatography tandem-mass spectrometry and automated solid-phase extraction is described. The method proved rugged, enables short turn-around times and is highly specific. Since there is growing evidence for the importance of therapeutic drug monitoring of itraconazole in the prophylaxis and treatment of invasive fungal infections, the method described here is of interest for a large number of tertiary care hospital laboratories. | |
| 540 | |a Copyright © 2003 by Walter de Gruyter GmbH & Co. KG | ||
| 690 | 7 | |a Medical equipment & techniques |2 nationallicence | |
| 690 | 7 | |a Medical diagnosis |2 nationallicence | |
| 690 | 7 | |a Diseases & disorders |2 nationallicence | |
| 700 | 1 | |a Vogeser |D Michael |4 aut | |
| 700 | 1 | |a Spöhrer |D Ute |4 aut | |
| 700 | 1 | |a Schiel |D Xaver |4 aut | |
| 773 | 0 | |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 41/7(2003-07-21), 915-920 |x 1434-6621 |q 41:7<915 |1 2003 |2 41 |o cclm | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/CCLM.2003.139 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/CCLM.2003.139 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Vogeser |D Michael |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Spöhrer |D Ute |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Schiel |D Xaver |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 41/7(2003-07-21), 915-920 |x 1434-6621 |q 41:7<915 |1 2003 |2 41 |o cclm | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||