caa a22 4500 378879146 CHVBK 20180305123427.0 cr unu---uuuuu 161128e20030721xx s 000 0 eng 10.1515/CCLM.2003.139 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.139 Determination of Itraconazole and Hydroxyitraconazole in Plasma by Use of LiquidChromatography-Tandem Mass Spectrometrywith On-line Solid-Phase Extraction [Elektronische Daten] [Michael Vogeser, Ute Spöhrer, Xaver Schiel] In this paper a method for the simultaneous quantification of the anti-fungal drug itraconazole and its co-active metabolite hydroxyitraconazole in plasma employing liquid chromatography tandem-mass spectrometry and automated solid-phase extraction is described. The method proved rugged, enables short turn-around times and is highly specific. Since there is growing evidence for the importance of therapeutic drug monitoring of itraconazole in the prophylaxis and treatment of invasive fungal infections, the method described here is of interest for a large number of tertiary care hospital laboratories. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Vogeser Michael aut Spöhrer Ute aut Schiel Xaver aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/7(2003-07-21), 915-920 1434-6621 41:7<915 2003 41 cclm https://doi.org/10.1515/CCLM.2003.139 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.139 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vogeser Michael aut NATIONALLICENCE 700 1- Spöhrer Ute aut NATIONALLICENCE 700 1- Schiel Xaver aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/7(2003-07-21), 915-920 1434-6621 41:7<915 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter