Polymorphisms in the IL-4 and IL-4R [α] Genesand Allergic Asthma
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 378879154 | ||
| 003 | CHVBK | ||
| 005 | 20180305123427.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 161128e20030721xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1515/CCLM.2003.134 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.134 | ||
| 245 | 0 | 0 | |a Polymorphisms in the IL-4 and IL-4R [α] Genesand Allergic Asthma |h [Elektronische Daten] |c [Tianpen Cui, Jianmin Wu, Shixiu Pan, Jungang Xie] |
| 520 | 3 | |a Allergic asthma is caused by genetic and environmental factors that interact to determine disease susceptibility and severity. Several lines of evidence suggest that the interleukin (IL)-4 gene and the IL-4-receptor α (IL-4Rα) gene are involved in the development of atopic diseases. We sought to determine whether two polymorphism sites in IL-4 and IL-4Rα chain were associated with allergic asthma in a Chinese population. We obtained DNA and clinical data from allergic asthma patients, which were compared with those of a group of healthy control subjects. The subjects were genotyped for the IL-4 C-590T promoter polymorphism and the IL-4R α chain Q576R by polymerase chain reaction-restriction fragment length polymorphism. The results showed that the IL-4 C-590T was not associated with allergic asthma in a Chinese population. However, the IL-4R α chain 576R/R was significantly increased in allergic asthma patients compared with control subjects (χ2=21.16; p < 0.01), and also total plasma immunoglobulin E (IgE) level was increased in allergic asthma patients. These data suggest that the IL-4R α chain 576R/R genotypes confer genetic susceptibility to allergic asthma in Chinese. | |
| 540 | |a Copyright (c) 2003 by Walter de Gruyter GmbH & Co. KG | ||
| 690 | 7 | |a Medical equipment & techniques |2 nationallicence | |
| 690 | 7 | |a Medical diagnosis |2 nationallicence | |
| 690 | 7 | |a Diseases & disorders |2 nationallicence | |
| 700 | 1 | |a Cui |D Tianpen |4 aut | |
| 700 | 1 | |a Wu |D Jianmin |4 aut | |
| 700 | 1 | |a Pan |D Shixiu |4 aut | |
| 700 | 1 | |a Xie |D Jungang |4 aut | |
| 773 | 0 | |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 41/7(2003-07-21), 888-892 |x 1434-6621 |q 41:7<888 |1 2003 |2 41 |o cclm | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/CCLM.2003.134 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/CCLM.2003.134 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cui |D Tianpen |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wu |D Jianmin |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pan |D Shixiu |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Xie |D Jungang |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 41/7(2003-07-21), 888-892 |x 1434-6621 |q 41:7<888 |1 2003 |2 41 |o cclm | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||