caa a22 4500 378879154 CHVBK 20180305123427.0 cr unu---uuuuu 161128e20030721xx s 000 0 eng 10.1515/CCLM.2003.134 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.134 Polymorphisms in the IL-4 and IL-4R [α] Genesand Allergic Asthma [Elektronische Daten] [Tianpen Cui, Jianmin Wu, Shixiu Pan, Jungang Xie] Allergic asthma is caused by genetic and environmental factors that interact to determine disease susceptibility and severity. Several lines of evidence suggest that the interleukin (IL)-4 gene and the IL-4-receptor α (IL-4Rα) gene are involved in the development of atopic diseases. We sought to determine whether two polymorphism sites in IL-4 and IL-4Rα chain were associated with allergic asthma in a Chinese population. We obtained DNA and clinical data from allergic asthma patients, which were compared with those of a group of healthy control subjects. The subjects were genotyped for the IL-4 C-590T promoter polymorphism and the IL-4R α chain Q576R by polymerase chain reaction-restriction fragment length polymorphism. The results showed that the IL-4 C-590T was not associated with allergic asthma in a Chinese population. However, the IL-4R α chain 576R/R was significantly increased in allergic asthma patients compared with control subjects (χ2=21.16; p < 0.01), and also total plasma immunoglobulin E (IgE) level was increased in allergic asthma patients. These data suggest that the IL-4R α chain 576R/R genotypes confer genetic susceptibility to allergic asthma in Chinese. Copyright (c) 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Cui Tianpen aut Wu Jianmin aut Pan Shixiu aut Xie Jungang aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/7(2003-07-21), 888-892 1434-6621 41:7<888 2003 41 cclm https://doi.org/10.1515/CCLM.2003.134 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.134 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cui Tianpen aut NATIONALLICENCE 700 1- Wu Jianmin aut NATIONALLICENCE 700 1- Pan Shixiu aut NATIONALLICENCE 700 1- Xie Jungang aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/7(2003-07-21), 888-892 1434-6621 41:7<888 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter