caa a22 4500 378879162 CHVBK 20180305123427.0 cr unu---uuuuu 161128e20030721xx s 000 0 eng 10.1515/CCLM.2003.127 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.127 Essential Hypertension: Genes and Dreams [Elektronische Daten] [Brian J. Morris, Adam V. Benjafield, Ruby C. Y. Lin] Herein we review all of the data from linkage by genome scanning and from association studies in essential hypertension. Genome scans have yielded loci linked to hypertension on almost every chromosome. We tabulate all of these loci to highlight the striking inconsistency. Similarly, association studies have implicated > 66 genes to date, which we also list, but virtually all have failed to show consistent replication in other settings. Nevertheless, we believe that molecular genetics should eventually find all of the major gene variants for essential hypertension. This will be a great scientific achievement and lead to new treatments. The dream, however, of using this information in clinical genetic testing could turn out to be a nightmare. Thus at present the hype surrounding genes for complex polygenic diseases like hypertension far exceeds the reality. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Morris Brian J. aut Benjafield Adam V. aut Lin Ruby C. Y. aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/7(2003-07-21), 834-844 1434-6621 41:7<834 2003 41 cclm https://doi.org/10.1515/CCLM.2003.127 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.127 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morris Brian J. aut NATIONALLICENCE 700 1- Benjafield Adam V. aut NATIONALLICENCE 700 1- Lin Ruby C. Y. aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/7(2003-07-21), 834-844 1434-6621 41:7<834 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter