caa a22 4500 378879189 CHVBK 20180305123427.0 cr unu---uuuuu 161128e20030721xx s 000 0 eng 10.1515/CCLM.2003.135 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.135 Circulating Transforming Growth Factor-β1, Lipoprotein(a) and Cellular Adhesion Molecules in Angiographically Assessed Coronary Artery Disease [Elektronische Daten] [Natasa Bogavac-Stanojevic, Srdjan Djurovic, Zorana Jelic-Ivanovic, Vesna Spasojevic- Kalimanovska, Dimitra Kalimanovska-Ostric] Transforming growth factor β1 (TGF-β1) is involved in different physiological and pathological processes, including atherogenesis. High plasma lipoprotein(a) (Lp(a)) concentration is an established independent risk factor that may interfere with the plasmin-mediated TGF-β1 activation. Both Lp(a) and TGF-β1 are thought to influence the expression of cellular adhesion molecules (CAMs), also involved in the process of atherogenesis. Whereas many studies confirmed the association between high plasma Lp(a) levels and coronary artery disease (CAD), conflicting results were obtained in different studies in which the changes of TGF-β1 and CAM concentrations in CAD patients were investigated. The aim of this case-control study was to explore the association of circulating TGF-β1, Lp(a) and CAMs (intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin) levels with the occurrence and severity of angiographically assessed coronary artery disease. Plasma TGF-β1, Lp(a), ICAM-1, VCAM-1 and E-selectin concentrations were measured in 100 patients with angiographically assessed CAD and 100 healthy blood donors matched according to age and gender. Lp(a) and TGF-β1 were significantly higher in patients than in healthy controls (p < 0.001 and p < 0.01, respectively), but no significant correlation between the TGF-β1 and Lp(a) values was found. The CAM concentrations obtained in CAD patients did not differ significantly as compared with the corresponding values in the controls. None of the measured parameters were influenced by the severity of CAD. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Bogavac-Stanojevic Natasa aut Djurovic Srdjan aut Jelic-Ivanovic Zorana aut Spasojevic- Kalimanovska Vesna aut Kalimanovska-Ostric Dimitra aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/7(2003-07-21), 893-898 1434-6621 41:7<893 2003 41 cclm https://doi.org/10.1515/CCLM.2003.135 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.135 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bogavac-Stanojevic Natasa aut NATIONALLICENCE 700 1- Djurovic Srdjan aut NATIONALLICENCE 700 1- Jelic-Ivanovic Zorana aut NATIONALLICENCE 700 1- Spasojevic- Kalimanovska Vesna aut NATIONALLICENCE 700 1- Kalimanovska-Ostric Dimitra aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/7(2003-07-21), 893-898 1434-6621 41:7<893 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter