caa a22 4500 378879243 CHVBK 20180305123428.0 cr unu---uuuuu 161128e20030721xx s 000 0 eng 10.1515/CCLM.2003.131 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.131 Nakane Masaki Soluble Guanylyl Cyclase: Physiological Role as an NO Receptor and the Potential MolecularTarget for Therapeutic Application [Elektronische Daten] [Masaki Nakane] Nitric oxide (NO) activates soluble guanylyl cyclase, which results in an increased synthesis of cyclic guanosine 3′,5′-cyclic monophosphate (cGMP), smooth muscle relaxation and vasodilation. The heme group in soluble guanylyl cyclase binds NO and allosterically activates the catalytic site. In addition, a second allosteric site that synergistically activates the enzyme has been reported. BAY 41-2272 was reported as an NO-independent activator of soluble guanylyl cyclase. Treatment with this compound results in anti-platelet activity, a decrease in blood pressure and an increase in survival, indicating a potential for treating cardiovascular diseases. YC-1, another NO-independent activator, activates soluble guanylyl cyclase and the activity is enhanced in the presence of NO. YC-1 relaxed tissue strips in organ bath. Consistent with its biochemical activity, YC-1 induced penile erection in a conscious rat model. Recently, we found a novel series of soluble guanylyl cyclase activators that also NO-independently activate soluble guanylyl cyclase and cause penile erection, suggesting a synergy with the endogenous NO production in vivo. Here I review the NO/cGMP signal transduction pathway and define soluble guanylyl cyclase modulators as a novel approach for the treatment of cardiovascular diseases and erectile dysfunction. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/7(2003-07-21), 865-870 1434-6621 41:7<865 2003 41 cclm https://doi.org/10.1515/CCLM.2003.131 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.131 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Nakane Masaki NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/7(2003-07-21), 865-870 1434-6621 41:7<865 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter