Balance of Pro- and Anti-Inflammatory Cytokines in Liver Surgery
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| 024 | 7 | 0 | |a 10.1515/CCLM.2003.136 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.136 | ||
| 245 | 0 | 0 | |a Balance of Pro- and Anti-Inflammatory Cytokines in Liver Surgery |h [Elektronische Daten] |c [Aleš Jerin, Neva Požar-Lukanovič, Valentin Sojar, Dragoje Stanisavljevič, Vesna Paver-Eržen, Joško Osredkar] |
| 520 | 3 | |a Inflammatory response in surgery is associated with the release of cytokines. Many cytokines are produced by macrophages; therefore surgical injuries to the liver may have great influence on the release of cytokines. Ischemia creates tissue injury and may contribute to the cytokine release. A balanced ratio of pro- and anti-inflammatory cytokines is important for appropriate immune response; excessive inflammation or hypo-responsiveness can lead to post-operative complications. To determine the magnitude of the cytokine response caused by liver surgery and to evaluate the balance of pro- and anti-inflammatory cytokines released during the operation, we measured levels of tumor necrosis factor-α (TNFα), interleukin (IL)-1β, IL-6 and IL-10 in 19 patients undergoing liver resection. The results showed a continuous rise of IL-6 and a transient elevation of IL-10. Levels of TNFα remained low; IL-1β was not detected at any sampling time. We conclude that liver surgery induces cytokine response characterized predominantly by an early appearance of IL-6 and IL-10, the elevation of IL-6 may be mainly caused by splanchnic ischemia. The IL-6/IL-10 ratio could possibly reflect the balance of pro- and anti-inflammatory cytokines in liver surgery better than the TNFα/IL-10 ratio, which can well represent inflammatory status in sepsis. | |
| 540 | |a Copyright © 2003 by Walter de Gruyter GmbH & Co. KG | ||
| 690 | 7 | |a Medical equipment & techniques |2 nationallicence | |
| 690 | 7 | |a Medical diagnosis |2 nationallicence | |
| 690 | 7 | |a Diseases & disorders |2 nationallicence | |
| 700 | 1 | |a Jerin |D Aleš |4 aut | |
| 700 | 1 | |a Požar-Lukanovič |D Neva |4 aut | |
| 700 | 1 | |a Sojar |D Valentin |4 aut | |
| 700 | 1 | |a Stanisavljevič |D Dragoje |4 aut | |
| 700 | 1 | |a Paver-Eržen |D Vesna |4 aut | |
| 700 | 1 | |a Osredkar |D Joško |4 aut | |
| 773 | 0 | |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 41/7(2003-07-21), 899-903 |x 1434-6621 |q 41:7<899 |1 2003 |2 41 |o cclm | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/CCLM.2003.136 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/CCLM.2003.136 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Jerin |D Aleš |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Požar-Lukanovič |D Neva |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sojar |D Valentin |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Stanisavljevič |D Dragoje |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Paver-Eržen |D Vesna |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Osredkar |D Joško |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 41/7(2003-07-21), 899-903 |x 1434-6621 |q 41:7<899 |1 2003 |2 41 |o cclm | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||