caa a22 4500 378879251 CHVBK 20180305123428.0 cr unu---uuuuu 161128e20030721xx s 000 0 eng 10.1515/CCLM.2003.136 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.136 Balance of Pro- and Anti-Inflammatory Cytokines in Liver Surgery [Elektronische Daten] [Aleš Jerin, Neva Požar-Lukanovič, Valentin Sojar, Dragoje Stanisavljevič, Vesna Paver-Eržen, Joško Osredkar] Inflammatory response in surgery is associated with the release of cytokines. Many cytokines are produced by macrophages; therefore surgical injuries to the liver may have great influence on the release of cytokines. Ischemia creates tissue injury and may contribute to the cytokine release. A balanced ratio of pro- and anti-inflammatory cytokines is important for appropriate immune response; excessive inflammation or hypo-responsiveness can lead to post-operative complications. To determine the magnitude of the cytokine response caused by liver surgery and to evaluate the balance of pro- and anti-inflammatory cytokines released during the operation, we measured levels of tumor necrosis factor-α (TNFα), interleukin (IL)-1β, IL-6 and IL-10 in 19 patients undergoing liver resection. The results showed a continuous rise of IL-6 and a transient elevation of IL-10. Levels of TNFα remained low; IL-1β was not detected at any sampling time. We conclude that liver surgery induces cytokine response characterized predominantly by an early appearance of IL-6 and IL-10, the elevation of IL-6 may be mainly caused by splanchnic ischemia. The IL-6/IL-10 ratio could possibly reflect the balance of pro- and anti-inflammatory cytokines in liver surgery better than the TNFα/IL-10 ratio, which can well represent inflammatory status in sepsis. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Jerin Aleš aut Požar-Lukanovič Neva aut Sojar Valentin aut Stanisavljevič Dragoje aut Paver-Eržen Vesna aut Osredkar Joško aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/7(2003-07-21), 899-903 1434-6621 41:7<899 2003 41 cclm https://doi.org/10.1515/CCLM.2003.136 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.136 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jerin Aleš aut NATIONALLICENCE 700 1- Požar-Lukanovič Neva aut NATIONALLICENCE 700 1- Sojar Valentin aut NATIONALLICENCE 700 1- Stanisavljevič Dragoje aut NATIONALLICENCE 700 1- Paver-Eržen Vesna aut NATIONALLICENCE 700 1- Osredkar Joško aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/7(2003-07-21), 899-903 1434-6621 41:7<899 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter