caa a22 4500 378879316 CHVBK 20180305123428.0 cr unu---uuuuu 161128e20030721xx s 000 0 eng 10.1515/CCLM.2003.142 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.142 Endocrine Alterations in the Aging Male [Elektronische Daten] [Martin W. Elmlinger, Thomas Dengler, Christoph Weinstock, Werner Kuehnel] The recent increase in the elderly population, current health trends and awareness of age-related changes in the male endocrine system, have led to discussions about the role of the hormonal changes in the aging process in males. Better prevention and treatment of suboptimal health status and age-related diseases in aging men are based on an improved understanding of aging, particularly of the significance of age-associated hormonal changes. The aims of this study were 1) to evaluate the age dependence of the serum concentrations of the following important hormonal parameters in adult males using the IMMULITE® 1 automated assay system (DPC, Los Angeles): testosterone, dehydro-epiandrosterone sulfate (DHEAS), estradiol (E2), sex hormone binding globulin (SHBG), lutropin (LH), follitropin (FSH), cortisol, prolactin, thyroid stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4) and the growth hormone-dependent parameters insulin-like growth factor (IGF-I) and IGF-binding protein-3 (IGFBP-3) and 2) to derive the following parameters: calculated free testosterone (cFT), ratio of calculated free testosterone to total testosterone (% cFT) and free androgen index (FAI). We found a significant decrease between the 1-30-year age group and the >70-year agegroup for total testosterone (−42.4%), FAI (−65.5%), cFT (−60.0%), % cFT (−30.0%), DHEAS (−71.9%), E2 (−35.4%), TSH (−23.6%), IGF-I (−40.3%) and IGFBP-3 (−26.5%). Since the decreases in the FAI and cFT were greater than that of total testosterone and because these derived parameters reflect the biologically active fraction of testosterone, FAI and cFT are better markers for androgen deficiency in males. In contrast, a significant increase with age was observed for SHBG (+61.2%73), LH (+40.0%), FSH (+98.3%) and cortisol (+54.2%). No significant alterations with age were observed for prolactin, fT3 and fT4. The study demonstrates that determining complete profiles of the androgenic, gonadotropic, adrenocortical, thyroid, pituitary and growth hormone/IGF endocrine axes in middle-aged and elderly men may be helpful in obtaining a correct clinical diagnosis for various hormonal disorders. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Elmlinger Martin W. aut Dengler Thomas aut Weinstock Christoph aut Kuehnel Werner aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/7(2003-07-21), 934-941 1434-6621 41:7<934 2003 41 cclm https://doi.org/10.1515/CCLM.2003.142 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.142 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Elmlinger Martin W. aut NATIONALLICENCE 700 1- Dengler Thomas aut NATIONALLICENCE 700 1- Weinstock Christoph aut NATIONALLICENCE 700 1- Kuehnel Werner aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/7(2003-07-21), 934-941 1434-6621 41:7<934 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter