caa a22 4500 378880993 CHVBK 20180305123431.0 cr unu---uuuuu 161128e20030514xx s 000 0 eng 10.1515/JPM.2003.032 doi (NATIONALLICENCE)gruyter-10.1515/JPM.2003.032 Amikacin alters auditory brainstem conduction time in newborns [Elektronische Daten] [A. Poblano, A. Belmont, J. Sosa, J. Ibarra, A. M. Vargas, G. Limón, C. Martínez] The purpose of this paper was to describe whether there are some relationships between amikacin serum levels and central conduction time in brainstem auditory evoked potentials (BAEP) within therapeutic range levels in newborns as index of drug toxicity in brainstem auditory centers in neonatally exposed infants. We performed a cross-sectional study to compare BAEP from 35 infants under amikacin administration and 24 control infants; both examinations were blinded to investigators. Bivariate and partial correlations were calculated between amikacin and BAEP measurements in treated infants. Amikacin determinations were within therapeutic levels.No clinical alterations in BAEP were found and no differences between amikacin-treated and control infants were found. Significant positive Pearson correlation between latency of I-III interwaves interval and amikacin Cmin serum levels was found and was present when calculations were controlled by partial correlations for gestational age at birth and Apgar score at 5 min.The findings suggest that increased amikacin levels in newborns are related to increased latencies in I-III interwave interval in infants, which may be an early index of brainstem effects of subclinical neurotoxicity of amikacin. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Human reproduction, growth & development nationallicence Gynaecology & obstetrics nationallicence Paediatric medicine nationallicence Poblano A. aut Belmont A. aut Sosa J. aut Ibarra J. aut Vargas A. M. aut Limón G. aut Martínez C. aut Journal of Perinatal Medicine Walter de Gruyter 31/3(2003-05-14), 237-241 0300-5577 31:3<237 2003 31 jpme https://doi.org/10.1515/JPM.2003.032 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/JPM.2003.032 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Poblano A. aut NATIONALLICENCE 700 1- Belmont A. aut NATIONALLICENCE 700 1- Sosa J. aut NATIONALLICENCE 700 1- Ibarra J. aut NATIONALLICENCE 700 1- Vargas A. M. aut NATIONALLICENCE 700 1- Limón G. aut NATIONALLICENCE 700 1- Martínez C. aut NATIONALLICENCE 773 0- Journal of Perinatal Medicine Walter de Gruyter 31/3(2003-05-14), 237-241 0300-5577 31:3<237 2003 31 jpme CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter