caa a22 4500 378881019 CHVBK 20180305123431.0 cr unu---uuuuu 161128e20030514xx s 000 0 eng 10.1515/JPM.2003.035 doi (NATIONALLICENCE)gruyter-10.1515/JPM.2003.035 Sequential use of thrombolytic agents for thrombosed mitral valve prosthesisduring pregnancy [Elektronische Daten] [A. H. Nassar, M. E. Abdallah, G. V. Moukarbel, I. M. Usta, W. S. Gharzuddine] Thrombolytic therapy has gained popularity as an alternative to surgery in the treatment of prosthetic heart valve thrombosis.We report on the sequential use of streptokinase followed by recombinant tissue type plasminogen activator (rt-PA) for the treatment of a thrombosed prosthetic mitral valve in a pregnant woman at 26 weeks of gestation. Although thrombolysis was unsuccessful, the patient carried till 34 weeks of gestation and delivered by cesarean section a live newborn with an uneventful postpartum course. Based on our case and on what has been previously described in the literature, thrombolytic therapy should be considered as an option in the management of hemodynamically unstable pregnant patients with prosthetic valve thrombosis.When a single agent proves insufficient, combination therapy should be considered as it might provide hemodynamic stability and improvement in cardiac function that would allow patients at a high surgical risk to carry their pregnancy to viability. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Human reproduction, growth & development nationallicence Gynaecology & obstetrics nationallicence Paediatric medicine nationallicence Nassar A. H. aut Abdallah M. E. aut Moukarbel G. V. aut Usta I. M. aut Gharzuddine W. S. aut Journal of Perinatal Medicine Walter de Gruyter 31/3(2003-05-14), 257-260 0300-5577 31:3<257 2003 31 jpme https://doi.org/10.1515/JPM.2003.035 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/JPM.2003.035 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nassar A. H. aut NATIONALLICENCE 700 1- Abdallah M. E. aut NATIONALLICENCE 700 1- Moukarbel G. V. aut NATIONALLICENCE 700 1- Usta I. M. aut NATIONALLICENCE 700 1- Gharzuddine W. S. aut NATIONALLICENCE 773 0- Journal of Perinatal Medicine Walter de Gruyter 31/3(2003-05-14), 257-260 0300-5577 31:3<257 2003 31 jpme CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter