caa a22 4500 378881442 CHVBK 20180305123432.0 cr unu---uuuuu 161128e20030807xx s 000 0 eng 10.1515/CCLM.2003.154 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.154 The Effect of Selenium on Immune Functions of J774.1 Cells [Elektronische Daten] [Nadia Safir, Albrecht Wendel, Rachid Saile, Layachi Chabraoui] The J774.1 macrophage cell line was used as a tool to investigate the influence of selenium on macrophage function. In vitro selenium supplementation enhanced phagocytosis, degranulation by the release of β-glucuronidase after N-formyl-methionyl-leucyl-phenylalanine (FMLP) or cytochalasin B, and the production of superoxide anion after phorbol myristate acetate stimulation of these cells, while the release of nitric oxide was not affected by the selenium status. Selenium supplementation enhanced significantly (p < 0.05) the release of tumor necrosis factor (5-fold), interleukin-1 (3-fold) and interleukin-6 (2.5-fold) after 10 μg/ml lipopolysaccharide stimulation compared to selenium-deficient cells. Copyright (c) 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Safir Nadia aut Wendel Albrecht aut Saile Rachid aut Chabraoui Layachi aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/8(2003-08-07), 1005-1011 1434-6621 41:8<1005 2003 41 cclm https://doi.org/10.1515/CCLM.2003.154 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.154 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Safir Nadia aut NATIONALLICENCE 700 1- Wendel Albrecht aut NATIONALLICENCE 700 1- Saile Rachid aut NATIONALLICENCE 700 1- Chabraoui Layachi aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/8(2003-08-07), 1005-1011 1434-6621 41:8<1005 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter