caa a22 4500 378881485 CHVBK 20180305123432.0 cr unu---uuuuu 161128e20030807xx s 000 0 eng 10.1515/CCLM.2003.167 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.167 Relationship of Dehydroepiandrosterone and Its 7-Hydroxylated Metabolites to Thyroid Parameters and Sex Hormone-Binding Globulin (SHBG) in Healthy Subjects [Elektronische Daten] [Richard Hampl, Martin Hill, Radovan Bílek, Luboslav Stárka] The concentrations of four immunomodulatory steroids, namely dehydroepiandrosterone (DHEA), its sulfate and its 7-hydroxylated metabolites, and sex hormone-binding globulin (SHBG) and major laboratory parameters of thyroid function were determined in sera from 104 healthy females and 48 males, screened for iodine deficiency in one region of the Czech Republic. The mutual relationships of the laboratory parameters were investigated by using four statistical approaches: correlation analysis, principal component analysis, canonical correlation and linear model relationship. In addition to expected correlations among thyroid parameters and substrate-product relationships among the steroids, several new relationships were revealed: The only thyroid parameter tightly correlating with SHBG was free triiodothyronine. The latter hormone was also associated with one of the 7-OH-DHEA epimers, namely with 7β-OH-DHEA. Thyroid hormones are known to possess thermogenic properties, as does another 7-oxygenated DHEA metabolite, 7-oxo-DHEA, the major metabolite of which is 7β-OH-DHEA. It may indicate a link between the two thermogenic factors. The results should serve for further investigation of changes in the thyroid hormone concentrations, together with SHBG and dehydroepiandrosterone metabolites, under various pathological situations. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Hampl Richard aut Hill Martin aut Bílek Radovan aut Stárka Luboslav aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/8(2003-08-07), 1081-1086 1434-6621 41:8<1081 2003 41 cclm https://doi.org/10.1515/CCLM.2003.167 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.167 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hampl Richard aut NATIONALLICENCE 700 1- Hill Martin aut NATIONALLICENCE 700 1- Bílek Radovan aut NATIONALLICENCE 700 1- Stárka Luboslav aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/8(2003-08-07), 1081-1086 1434-6621 41:8<1081 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter