Clinical B12 Deficiency in One Case of Recurrent Spontaneous Pregnancy Loss
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| 024 | 7 | 0 | |a 10.1515/CCLM.2003.157 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.157 | ||
| 245 | 0 | 0 | |a Clinical B12 Deficiency in One Case of Recurrent Spontaneous Pregnancy Loss |h [Elektronische Daten] |c [Mirande Candito, Sarah Magnaldo, Jacques Bayle, Jean-François Dor, Yves Gillet, André Bongain, Emmanuel Van Obberghen] |
| 520 | 3 | |a Moderate hyperhomocysteinaemia (HHcy) and the homozygous mutation C677T in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene are associated with increased risk of recurrent pregnancy loss. This HHcy is currently reported as a consequence of folate rather than of vitamin B12-deficient status. We describe one case of recurrent early pregnancy loss with HHcy caused by B12 deficiency. A 38-year old woman had four episodes of early spontaneous pregnancy loss. Biological data: no haemostasis disorders, HHcy (25.9 μmol/l), normal folate (5 ng/ml), B12 deficiency (<150 pg/ml) and the MTHFR C677T homozygote genotype. A bone marrow biopsy gave evidence of moderate megaloblastosis. Parenteral B12 therapy led to normal homocysteine level within 2 months and to a successful pregnancy. In conclusion, vitamin B12 deficiency is one of the causes of recurrent pregnancy loss associated with HHcy, and serum B12 should be measured systematically in this circumstance. | |
| 540 | |a Copyright © 2003 by Walter de Gruyter GmbH & Co. KG | ||
| 690 | 7 | |a Medical equipment & techniques |2 nationallicence | |
| 690 | 7 | |a Medical diagnosis |2 nationallicence | |
| 690 | 7 | |a Diseases & disorders |2 nationallicence | |
| 700 | 1 | |a Candito |D Mirande |4 aut | |
| 700 | 1 | |a Magnaldo |D Sarah |4 aut | |
| 700 | 1 | |a Bayle |D Jacques |4 aut | |
| 700 | 1 | |a Dor |D Jean-François |4 aut | |
| 700 | 1 | |a Gillet |D Yves |4 aut | |
| 700 | 1 | |a Bongain |D André |4 aut | |
| 700 | 1 | |a Obberghen |D Emmanuel Van |4 aut | |
| 773 | 0 | |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 41/8(2003-08-07), 1026-1027 |x 1434-6621 |q 41:8<1026 |1 2003 |2 41 |o cclm | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/CCLM.2003.157 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/CCLM.2003.157 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Candito |D Mirande |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Magnaldo |D Sarah |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bayle |D Jacques |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dor |D Jean-François |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gillet |D Yves |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bongain |D André |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Obberghen |D Emmanuel Van |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 41/8(2003-08-07), 1026-1027 |x 1434-6621 |q 41:8<1026 |1 2003 |2 41 |o cclm | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||