caa a22 4500 378881523 CHVBK 20180305123433.0 cr unu---uuuuu 161128e20030807xx s 000 0 eng 10.1515/CCLM.2003.166 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2003.166 Biological Variation of Lipoprotein(a) in a Diabetic Population. Analysis of the Causes and Clinical Implications [Elektronische Daten] [Cristina Hernández, Gemma Francisco, Pilar Chacón, Jordi Mesa, Rafael Simó] The aims of the present study were to evaluate the biological variability of lipoprotein(a) (Lp(a)) in diabetic patients and to investigate the biological sources of this variability. Lp(a) was measured by ELISA in four serum specimens collected in 3-month intervals from 70 patients. The other parameters analyzed were: total cholesterol, high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), triglycerides, glucose, HbA and albumin excretion rate. The overall biological within-subject variance (CVb) was 31.7%, and it was inversely correlated with Lp(a) serum levels. According to the initial ranges of Lp(a) serum levels (<15, 15-30 and >30mg/dl) the CVb were 42.3%, 24.1% and 23.7%, respectively. In multivariate analysis the total intra-individual coefficient of variation (CVt) of triglycerides and the CVt of the albumin excretion rate (AER) were independently associated with the CVb of Lp(a) (R2 =0.54). The intra-individual biological variation of Lp(a) produced a misclassification of 20% of diabetic patients for cardiovascular risk attributable to this lipoprotein. In conclusion, the higher biological variability of Lp(a) observed in diabetic patients suggests that a single determination could be inaccurate to assess the cardiovascular risk associated with this lipoprotein, at least in those patients in whom serum levels are near the cut-off considered as risk for cardiovascular disease (>30 mg/dl). Finally, triglycerides and AER are the main factors influencing Lp(a) serum levels in the diabetic population. Copyright © 2003 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Hernández Cristina aut Francisco Gemma aut Chacón Pilar aut Mesa Jordi aut Simó Rafael aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/8(2003-08-07), 1075-1080 1434-6621 41:8<1075 2003 41 cclm https://doi.org/10.1515/CCLM.2003.166 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2003.166 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hernández Cristina aut NATIONALLICENCE 700 1- Francisco Gemma aut NATIONALLICENCE 700 1- Chacón Pilar aut NATIONALLICENCE 700 1- Mesa Jordi aut NATIONALLICENCE 700 1- Simó Rafael aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 41/8(2003-08-07), 1075-1080 1434-6621 41:8<1075 2003 41 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter