Hydroxy-alkyl bisphosphonic acid partial esters (HABPA-PE): Structures of two symmetrical and non-symmetrical members of a new class of prodrugs in bone disease treatments
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| 024 | 7 | 0 | |a 10.1524/zkri.218.6.445.20719 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1524/zkri.218.6.445.20719 | ||
| 245 | 0 | 0 | |a Hydroxy-alkyl bisphosphonic acid partial esters (HABPA-PE): Structures of two symmetrical and non-symmetrical members of a new class of prodrugs in bone disease treatments |h [Elektronische Daten] |c [C. Barbey, M. Lecouvey, I. Mallard, Th. Prangé, A. Neuman, M. Lance, A. Navaza] |
| 520 | 3 | |a Two new hydroxy alkyl bisphosphonate partial esters (HABPA-PE) have been crystallised. The first compound C6H15NaO7P2C2H5O, crystallises as an ethanol solvate and forms rigid infinite β-sheet-like ribbons. The second, C6H16O7P2, displays self-association in dimers. In these new structures, packing analyses confirm the enhanced hydrophobic character due to partial esterification compared to naked hydroxybisphosphonic acids and the simplification of their H bonding patterns. | |
| 540 | |a © 2003 Oldenbourg Wissenschaftsverlag GmbH | ||
| 690 | 7 | |a Crystallography |2 nationallicence | |
| 690 | 7 | |a Inorganic chemistry |2 nationallicence | |
| 690 | 7 | |a Organic chemistry |2 nationallicence | |
| 700 | 1 | |a Barbey |D C. |4 aut | |
| 700 | 1 | |a Lecouvey |D M. |4 aut | |
| 700 | 1 | |a Mallard |D I. |4 aut | |
| 700 | 1 | |a Prangé |D Th |4 aut | |
| 700 | 1 | |a Neuman |D A. |4 aut | |
| 700 | 1 | |a Lance |D M. |4 aut | |
| 700 | 1 | |a Navaza |D A. |4 aut | |
| 773 | 0 | |t Zeitschrift für Kristallographie - Crystalline Materials |d De Gruyter Oldenbourg |g 218/6(2003-06-01), 445-449 |x 2194-4946 |q 218:6<445 |1 2003 |2 218 |o zkri | |
| 856 | 4 | 0 | |u https://doi.org/10.1524/zkri.218.6.445.20719 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1524/zkri.218.6.445.20719 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Barbey |D C. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lecouvey |D M. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mallard |D I. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Prangé |D Th |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Neuman |D A. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lance |D M. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Navaza |D A. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Zeitschrift für Kristallographie - Crystalline Materials |d De Gruyter Oldenbourg |g 218/6(2003-06-01), 445-449 |x 2194-4946 |q 218:6<445 |1 2003 |2 218 |o zkri | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||