Plasma endothelin-1 and clinical manifestations of neonatal sepsis
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| 024 | 7 | 0 | |a 10.1515/JPM.2004.126 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/JPM.2004.126 | ||
| 245 | 0 | 0 | |a Plasma endothelin-1 and clinical manifestations of neonatal sepsis |h [Elektronische Daten] |c [José Figueras-Aloy, Lilian Gómez-Lopez, J. Manuel Rodríguéz-Miguélez, Yolanda Jordán-García, M. Dolores Salvia-Roiges, Wladimiro Jiménez, Xavier Carbonell-Estrany] |
| 520 | 3 | |a Aim: To determine whether plasma endothelin-1 (ET-1) relates to clinical manifestations of sepsis in the newborn, especially with systemic hypotension, acidosis, severe hypoxemia (which may represent pulmonary hypertension) and oliguria. Methods: Prospective study of 35 consecutive newborns with clinical sepsis: 22 with hemoculture-positive (HC+) sepsis and 13 hemoculture-negative (HC-). Plasma ET-1 concentrations were measured within 2 days of the diagnosis of sepsis. SNAP-II severity score was performed at the time of highest clinical severity. Results: Newborns with HC+ sepsis had higher plasma ET-1 concentrations and SNAP-II scores (especially PO2/FiO2ratio) than HC- septic children. Plasma ET-1 concentrations increased linearly with each item of the SNAP-II score, but only reached significant differences in lowest mean blood pressure (P=0.030), lowest pH (P=0.048), multiple seizures (P=0.010) and lowest urine output (P=0.013). Leukocyte count, immature/total neutrophil ratio and C-reactive protein value were not different. Each item of the SNAP-II score was independently related only to ET-1 level. Oliguria, acidosis and systemic hypotension were more correlated (R2>0.5). Conclusions: Plasma ET-1 levels in neonatal sepsis are related to the severity of clinical manifestations, especially oliguria, acidosis and systemic hypotension. | |
| 540 | |a © Walter de Gruyter | ||
| 690 | 7 | |a Human reproduction, growth & development |2 nationallicence | |
| 690 | 7 | |a Gynaecology & obstetrics |2 nationallicence | |
| 690 | 7 | |a Paediatric medicine |2 nationallicence | |
| 690 | 7 | |a endothelin-1 |2 nationallicence | |
| 690 | 7 | |a hypoxemia |2 nationallicence | |
| 690 | 7 | |a newborn |2 nationallicence | |
| 690 | 7 | |a oliguria |2 nationallicence | |
| 690 | 7 | |a pulmonary hypertension |2 nationallicence | |
| 690 | 7 | |a sepsis |2 nationallicence | |
| 690 | 7 | |a seizures |2 nationallicence | |
| 690 | 7 | |a SNAP-II |2 nationallicence | |
| 690 | 7 | |a systemic hypotension |2 nationallicence | |
| 700 | 1 | |a Figueras-Aloy |D José |u Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic |4 aut | |
| 700 | 1 | |a Gómez-Lopez |D Lilian |u Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic |4 aut | |
| 700 | 1 | |a Rodríguéz-Miguélez |D J. Manuel |u Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic |4 aut | |
| 700 | 1 | |a Jordán-García |D Yolanda |u Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic |4 aut | |
| 700 | 1 | |a Salvia-Roiges |D M. Dolores |u Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic |4 aut | |
| 700 | 1 | |a Jiménez |D Wladimiro |u Hormonal Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain |4 aut | |
| 700 | 1 | |a Carbonell-Estrany |D Xavier |u Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic |4 aut | |
| 773 | 0 | |t Journal of Perinatal Medicine |d Walter de Gruyter |g 32/6(2004-11-04), 522-526 |x 0300-5577 |q 32:6<522 |1 2004 |2 32 |o jpme | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/JPM.2004.126 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/JPM.2004.126 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Figueras-Aloy |D José |u Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gómez-Lopez |D Lilian |u Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rodríguéz-Miguélez |D J. Manuel |u Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Jordán-García |D Yolanda |u Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Salvia-Roiges |D M. Dolores |u Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Jiménez |D Wladimiro |u Hormonal Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Carbonell-Estrany |D Xavier |u Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Perinatal Medicine |d Walter de Gruyter |g 32/6(2004-11-04), 522-526 |x 0300-5577 |q 32:6<522 |1 2004 |2 32 |o jpme | ||
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| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||