caa a22 4500 378882732 CHVBK 20180305123435.0 cr unu---uuuuu 161128e20041104xx s 000 0 eng 10.1515/JPM.2004.126 doi (NATIONALLICENCE)gruyter-10.1515/JPM.2004.126 Plasma endothelin-1 and clinical manifestations of neonatal sepsis [Elektronische Daten] [José Figueras-Aloy, Lilian Gómez-Lopez, J. Manuel Rodríguéz-Miguélez, Yolanda Jordán-García, M. Dolores Salvia-Roiges, Wladimiro Jiménez, Xavier Carbonell-Estrany] Aim: To determine whether plasma endothelin-1 (ET-1) relates to clinical manifestations of sepsis in the newborn, especially with systemic hypotension, acidosis, severe hypoxemia (which may represent pulmonary hypertension) and oliguria. Methods: Prospective study of 35 consecutive newborns with clinical sepsis: 22 with hemoculture-positive (HC+) sepsis and 13 hemoculture-negative (HC-). Plasma ET-1 concentrations were measured within 2 days of the diagnosis of sepsis. SNAP-II severity score was performed at the time of highest clinical severity. Results: Newborns with HC+ sepsis had higher plasma ET-1 concentrations and SNAP-II scores (especially PO2/FiO2ratio) than HC- septic children. Plasma ET-1 concentrations increased linearly with each item of the SNAP-II score, but only reached significant differences in lowest mean blood pressure (P=0.030), lowest pH (P=0.048), multiple seizures (P=0.010) and lowest urine output (P=0.013). Leukocyte count, immature/total neutrophil ratio and C-reactive protein value were not different. Each item of the SNAP-II score was independently related only to ET-1 level. Oliguria, acidosis and systemic hypotension were more correlated (R2>0.5). Conclusions: Plasma ET-1 levels in neonatal sepsis are related to the severity of clinical manifestations, especially oliguria, acidosis and systemic hypotension. © Walter de Gruyter Human reproduction, growth & development nationallicence Gynaecology & obstetrics nationallicence Paediatric medicine nationallicence endothelin-1 nationallicence hypoxemia nationallicence newborn nationallicence oliguria nationallicence pulmonary hypertension nationallicence sepsis nationallicence seizures nationallicence SNAP-II nationallicence systemic hypotension nationallicence Figueras-Aloy José Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic aut Gómez-Lopez Lilian Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic aut Rodríguéz-Miguélez J. Manuel Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic aut Jordán-García Yolanda Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic aut Salvia-Roiges M. Dolores Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic aut Jiménez Wladimiro Hormonal Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain aut Carbonell-Estrany Xavier Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic aut Journal of Perinatal Medicine Walter de Gruyter 32/6(2004-11-04), 522-526 0300-5577 32:6<522 2004 32 jpme https://doi.org/10.1515/JPM.2004.126 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/JPM.2004.126 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Figueras-Aloy José Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic aut NATIONALLICENCE 700 1- Gómez-Lopez Lilian Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic aut NATIONALLICENCE 700 1- Rodríguéz-Miguélez J. Manuel Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic aut NATIONALLICENCE 700 1- Jordán-García Yolanda Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic aut NATIONALLICENCE 700 1- Salvia-Roiges M. Dolores Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic aut NATIONALLICENCE 700 1- Jiménez Wladimiro Hormonal Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Carbonell-Estrany Xavier Neonatal Service, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Unitat Integrada de Pediatria, Hospital Clinic aut NATIONALLICENCE 773 0- Journal of Perinatal Medicine Walter de Gruyter 32/6(2004-11-04), 522-526 0300-5577 32:6<522 2004 32 jpme CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter