Effects of nitric oxide and prostacyclin on hemodynamic response by big endothelin-1 in near term fetal sheep
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| 024 | 7 | 0 | |a 10.1515/JPM.2004.149 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/JPM.2004.149 | ||
| 245 | 0 | 0 | |a Effects of nitric oxide and prostacyclin on hemodynamic response by big endothelin-1 in near term fetal sheep |h [Elektronische Daten] |c [Toshiaki Okawa, Shinya Honda, Minoru Sanpei, Tomohiko Ishida, Keiya Fujimori, Akira Sato] |
| 520 | 3 | |a Aims: To measure plasma concentrations of endothelin (ET)-1, NO metabolites (nitrate/nitrite; NOx) and 6-keto PGF1α (PGF1α) in maternal and fetal sheep blood, and to evaluate the effects of big ET-1 on hemodynamic response, blood gases and NO and 6-keto PGF1α production in near term fetal sheep. Methods: Hemodynamic parameters were measured during infusion of big ET-1 into the carotid vein in chronically catheterized fetal sheep on day 125 of gestation. Fetal arterial blood samples were obtained for ET-1, PGF1α) and nitrate/nitrite (NOx) measurements. Results: ET-1, NOx and PGF1α plasma concentrations were all significantly higher in fetal compared with the maternal plasma. Big ET-1 significantly decreased fetal systolic and diastolic blood pressure and significantly increased fetal heart rate. Big ET-1 stimulated plasma PGF1α), but not NOx, concentration. Conclusions: Circulatory regulating factors in the fetus were up-regulated. The effects of ET-1 on fetal hemodynamic respnse may be mediated via prostacyclin, but not via the NO pathway. | |
| 540 | |a © Walter de Gruyter | ||
| 690 | 7 | |a Human reproduction, growth & development |2 nationallicence | |
| 690 | 7 | |a Gynaecology & obstetrics |2 nationallicence | |
| 690 | 7 | |a Paediatric medicine |2 nationallicence | |
| 690 | 7 | |a big endothelin-1 |2 nationallicence | |
| 690 | 7 | |a fetus |2 nationallicence | |
| 690 | 7 | |a hypotension |2 nationallicence | |
| 690 | 7 | |a 6-keto PGF1α) |2 nationallicence | |
| 690 | 7 | |a nitric oxide |2 nationallicence | |
| 690 | 7 | |a sheep |2 nationallicence | |
| 700 | 1 | |a Okawa |D Toshiaki |u Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan |4 aut | |
| 700 | 1 | |a Honda |D Shinya |u Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan |4 aut | |
| 700 | 1 | |a Sanpei |D Minoru |u Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan |4 aut | |
| 700 | 1 | |a Ishida |D Tomohiko |u Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan |4 aut | |
| 700 | 1 | |a Fujimori |D Keiya |u Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan |4 aut | |
| 700 | 1 | |a Sato |D Akira |u Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan |4 aut | |
| 773 | 0 | |t Journal of Perinatal Medicine |d Walter de Gruyter |g 32/6(2004-11-04), 495-499 |x 0300-5577 |q 32:6<495 |1 2004 |2 32 |o jpme | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/JPM.2004.149 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/JPM.2004.149 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Okawa |D Toshiaki |u Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Honda |D Shinya |u Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sanpei |D Minoru |u Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ishida |D Tomohiko |u Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fujimori |D Keiya |u Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sato |D Akira |u Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Perinatal Medicine |d Walter de Gruyter |g 32/6(2004-11-04), 495-499 |x 0300-5577 |q 32:6<495 |1 2004 |2 32 |o jpme | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||