caa a22 4500 378882791 CHVBK 20180305123435.0 cr unu---uuuuu 161128e20041104xx s 000 0 eng 10.1515/JPM.2004.149 doi (NATIONALLICENCE)gruyter-10.1515/JPM.2004.149 Effects of nitric oxide and prostacyclin on hemodynamic response by big endothelin-1 in near term fetal sheep [Elektronische Daten] [Toshiaki Okawa, Shinya Honda, Minoru Sanpei, Tomohiko Ishida, Keiya Fujimori, Akira Sato] Aims: To measure plasma concentrations of endothelin (ET)-1, NO metabolites (nitrate/nitrite; NOx) and 6-keto PGF1α (PGF1α) in maternal and fetal sheep blood, and to evaluate the effects of big ET-1 on hemodynamic response, blood gases and NO and 6-keto PGF1α production in near term fetal sheep. Methods: Hemodynamic parameters were measured during infusion of big ET-1 into the carotid vein in chronically catheterized fetal sheep on day 125 of gestation. Fetal arterial blood samples were obtained for ET-1, PGF1α) and nitrate/nitrite (NOx) measurements. Results: ET-1, NOx and PGF1α plasma concentrations were all significantly higher in fetal compared with the maternal plasma. Big ET-1 significantly decreased fetal systolic and diastolic blood pressure and significantly increased fetal heart rate. Big ET-1 stimulated plasma PGF1α), but not NOx, concentration. Conclusions: Circulatory regulating factors in the fetus were up-regulated. The effects of ET-1 on fetal hemodynamic respnse may be mediated via prostacyclin, but not via the NO pathway. © Walter de Gruyter Human reproduction, growth & development nationallicence Gynaecology & obstetrics nationallicence Paediatric medicine nationallicence big endothelin-1 nationallicence fetus nationallicence hypotension nationallicence 6-keto PGF1α) nationallicence nitric oxide nationallicence sheep nationallicence Okawa Toshiaki Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan aut Honda Shinya Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan aut Sanpei Minoru Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan aut Ishida Tomohiko Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan aut Fujimori Keiya Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan aut Sato Akira Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan aut Journal of Perinatal Medicine Walter de Gruyter 32/6(2004-11-04), 495-499 0300-5577 32:6<495 2004 32 jpme https://doi.org/10.1515/JPM.2004.149 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/JPM.2004.149 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Okawa Toshiaki Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan aut NATIONALLICENCE 700 1- Honda Shinya Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan aut NATIONALLICENCE 700 1- Sanpei Minoru Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan aut NATIONALLICENCE 700 1- Ishida Tomohiko Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan aut NATIONALLICENCE 700 1- Fujimori Keiya Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan aut NATIONALLICENCE 700 1- Sato Akira Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan aut NATIONALLICENCE 773 0- Journal of Perinatal Medicine Walter de Gruyter 32/6(2004-11-04), 495-499 0300-5577 32:6<495 2004 32 jpme CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter