SR-A1, a member of the human pre-mRNA splicing factor family, and its expression in colon cancer progression
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| 024 | 7 | 0 | |a 10.1515/BC.2004.102 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/BC.2004.102 | ||
| 245 | 0 | 0 | |a SR-A1, a member of the human pre-mRNA splicing factor family, and its expression in colon cancer progression |h [Elektronische Daten] |c [Konstantina Mathioudaki, Theoni Leotsakou, Alexandra Papadokostopoulou, Emmanouil Paraskevas, Alexandros Ardavanis, Maroulio Talieri, Andreas Scorilas] |
| 520 | 3 | |a SR (serine-arginine) proteins are essential pre-mRNA splicing factors. Several SR proteins have been characterized in humans, among them SR-A1. It has been demonstrated by members of our group that the SR-A1 gene is constitutively expressed in most of the human tissues, while its transcription is increased in breast carcinoma cell lines. Moreover, the SR-A1 gene is overexpressed in a set of ovarian tumors, suggesting that it may be involved in the pathogenesis and/or progression of ovarian cancer. Therefore, in the present study we examined the expression of the SR-A1 gene in colon cancer tissues by RT-PCR and found that it is overexpressed as compared to normal mucosa (p=0.01). The SR-A1 gene was expressed more frequently in well-differentiated tumors than those with poor differentiation. Survival curves determined by the Kaplan-Meier method and univariate analysis demonstrated that SR-A1-positivity is associated with a long survival (p=0.044). However, when entered into a Cox multivariate model adjusted for other clinicopathological features studied, SR-A1 expression status was not found to be of independent prognostic significance. To the best of our knowledge, this is the first study examining the expression of the novel gene SR-A1 in colon cancer progression. | |
| 540 | |a © Walter de Gruyter | ||
| 690 | 7 | |a Biochemistry |2 nationallicence | |
| 690 | 7 | |a Molecular biology |2 nationallicence | |
| 690 | 7 | |a Cellular biology |2 nationallicence | |
| 690 | 7 | |a colon cancer |2 nationallicence | |
| 690 | 7 | |a SR-A1 |2 nationallicence | |
| 690 | 7 | |a SR proteins |2 nationallicence | |
| 700 | 1 | |a Mathioudaki |D Konstantina |u ‘G. Papanicolaou' Research Center of Oncology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece |4 aut | |
| 700 | 1 | |a Leotsakou |D Theoni |u ‘G. Papanicolaou' Research Center of Oncology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece |4 aut | |
| 700 | 1 | |a Papadokostopoulou |D Alexandra |u Department of Gastroenterology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece |4 aut | |
| 700 | 1 | |a Paraskevas |D Emmanouil |u Department of Gastroenterology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece |4 aut | |
| 700 | 1 | |a Ardavanis |D Alexandros |u 1st Department of Medical Oncology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece |4 aut | |
| 700 | 1 | |a Talieri |D Maroulio |u ‘G. Papanicolaou' Research Center of Oncology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece |4 aut | |
| 700 | 1 | |a Scorilas |D Andreas |u Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, GR-15711 Athens, Greece |4 aut | |
| 773 | 0 | |t Biological Chemistry |d Walter de Gruyter |g 385/9(2004-09-01), 785-790 |x 1431-6730 |q 385:9<785 |1 2004 |2 385 |o bchm | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/BC.2004.102 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/BC.2004.102 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mathioudaki |D Konstantina |u ‘G. Papanicolaou' Research Center of Oncology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Leotsakou |D Theoni |u ‘G. Papanicolaou' Research Center of Oncology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Papadokostopoulou |D Alexandra |u Department of Gastroenterology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Paraskevas |D Emmanouil |u Department of Gastroenterology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ardavanis |D Alexandros |u 1st Department of Medical Oncology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Talieri |D Maroulio |u ‘G. Papanicolaou' Research Center of Oncology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Scorilas |D Andreas |u Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, GR-15711 Athens, Greece |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Biological Chemistry |d Walter de Gruyter |g 385/9(2004-09-01), 785-790 |x 1431-6730 |q 385:9<785 |1 2004 |2 385 |o bchm | ||
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