caa a22 4500 378884026 CHVBK 20180305123438.0 cr unu---uuuuu 161128e20040901xx s 000 0 eng 10.1515/BC.2004.102 doi (NATIONALLICENCE)gruyter-10.1515/BC.2004.102 SR-A1, a member of the human pre-mRNA splicing factor family, and its expression in colon cancer progression [Elektronische Daten] [Konstantina Mathioudaki, Theoni Leotsakou, Alexandra Papadokostopoulou, Emmanouil Paraskevas, Alexandros Ardavanis, Maroulio Talieri, Andreas Scorilas] SR (serine-arginine) proteins are essential pre-mRNA splicing factors. Several SR proteins have been characterized in humans, among them SR-A1. It has been demonstrated by members of our group that the SR-A1 gene is constitutively expressed in most of the human tissues, while its transcription is increased in breast carcinoma cell lines. Moreover, the SR-A1 gene is overexpressed in a set of ovarian tumors, suggesting that it may be involved in the pathogenesis and/or progression of ovarian cancer. Therefore, in the present study we examined the expression of the SR-A1 gene in colon cancer tissues by RT-PCR and found that it is overexpressed as compared to normal mucosa (p=0.01). The SR-A1 gene was expressed more frequently in well-differentiated tumors than those with poor differentiation. Survival curves determined by the Kaplan-Meier method and univariate analysis demonstrated that SR-A1-positivity is associated with a long survival (p=0.044). However, when entered into a Cox multivariate model adjusted for other clinicopathological features studied, SR-A1 expression status was not found to be of independent prognostic significance. To the best of our knowledge, this is the first study examining the expression of the novel gene SR-A1 in colon cancer progression. © Walter de Gruyter Biochemistry nationallicence Molecular biology nationallicence Cellular biology nationallicence colon cancer nationallicence SR-A1 nationallicence SR proteins nationallicence Mathioudaki Konstantina ‘G. Papanicolaou' Research Center of Oncology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut Leotsakou Theoni ‘G. Papanicolaou' Research Center of Oncology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut Papadokostopoulou Alexandra Department of Gastroenterology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut Paraskevas Emmanouil Department of Gastroenterology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut Ardavanis Alexandros 1st Department of Medical Oncology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut Talieri Maroulio ‘G. Papanicolaou' Research Center of Oncology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut Scorilas Andreas Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, GR-15711 Athens, Greece aut Biological Chemistry Walter de Gruyter 385/9(2004-09-01), 785-790 1431-6730 385:9<785 2004 385 bchm https://doi.org/10.1515/BC.2004.102 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/BC.2004.102 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mathioudaki Konstantina ‘G. Papanicolaou' Research Center of Oncology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut NATIONALLICENCE 700 1- Leotsakou Theoni ‘G. Papanicolaou' Research Center of Oncology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut NATIONALLICENCE 700 1- Papadokostopoulou Alexandra Department of Gastroenterology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut NATIONALLICENCE 700 1- Paraskevas Emmanouil Department of Gastroenterology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut NATIONALLICENCE 700 1- Ardavanis Alexandros 1st Department of Medical Oncology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut NATIONALLICENCE 700 1- Talieri Maroulio ‘G. Papanicolaou' Research Center of Oncology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut NATIONALLICENCE 700 1- Scorilas Andreas Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, GR-15711 Athens, Greece aut NATIONALLICENCE 773 0- Biological Chemistry Walter de Gruyter 385/9(2004-09-01), 785-790 1431-6730 385:9<785 2004 385 bchm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter