caa a22 4500 378884077 CHVBK 20180305123438.0 cr unu---uuuuu 161128e20040901xx s 000 0 eng 10.1515/BC.2004.101 doi (NATIONALLICENCE)gruyter-10.1515/BC.2004.101 Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer [Elektronische Daten] [Konstantina Mathioudaki, Andreas Scorilas, Alexandra Papadokostopoulou, Dimitrios Xynopoulos, Niki Arnogianaki, Niki Agnanti, Maroulio Talieri] Apoptosis is an active process regulated by a variety of genes. Recently, the molecular cloning, physical mapping and expression analysis of a novel gene of the Bcl-2 family, BCL2L12, was reported. Expression analysis of the BCL2L12 gene in breast cancer confirmed an association of BCL2L12 with favorable prognosis of patients. In the present study, the expression of the BCL2L12 gene was analyzed in colon cancer by RT-PCR. Two transcripts, BCL2L12 and BCL2L12-A, were overexpressed in the cancer tissues as compared to their paired normal mucosa. An association was found between BCL2L12-A transcript expression and nodal status, as well as Dukes' stage. The BCL2L12-A transcript appears to be of importance for colon cancer since its expression is associated with disease progression. © Walter de Gruyter Biochemistry nationallicence Molecular biology nationallicence Cellular biology nationallicence apoptosis nationallicence BCL2L12 nationallicence colon cancer nationallicence Mathioudaki Konstantina G. Papanicolaou Research Center of Oncology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut Scorilas Andreas Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens GR-15711 Athens, Greece aut Papadokostopoulou Alexandra Department of Gastroenterology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut Xynopoulos Dimitrios Department of Gastroenterology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut Arnogianaki Niki Department of Pathology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut Agnanti Niki Department of Pathology, Medical School, University of Ioannina, GR-45110, Greece aut Talieri Maroulio G. Papanicolaou Research Center of Oncology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut Biological Chemistry Walter de Gruyter 385/9(2004-09-01), 779-783 1431-6730 385:9<779 2004 385 bchm https://doi.org/10.1515/BC.2004.101 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/BC.2004.101 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mathioudaki Konstantina G. Papanicolaou Research Center of Oncology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut NATIONALLICENCE 700 1- Scorilas Andreas Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens GR-15711 Athens, Greece aut NATIONALLICENCE 700 1- Papadokostopoulou Alexandra Department of Gastroenterology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut NATIONALLICENCE 700 1- Xynopoulos Dimitrios Department of Gastroenterology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut NATIONALLICENCE 700 1- Arnogianaki Niki Department of Pathology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut NATIONALLICENCE 700 1- Agnanti Niki Department of Pathology, Medical School, University of Ioannina, GR-45110, Greece aut NATIONALLICENCE 700 1- Talieri Maroulio G. Papanicolaou Research Center of Oncology, ‘Saint Savas' Hospital, GR-11522 Athens, Greece aut NATIONALLICENCE 773 0- Biological Chemistry Walter de Gruyter 385/9(2004-09-01), 779-783 1431-6730 385:9<779 2004 385 bchm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter