Inhibition of inducible TNF-α expression by oxaspirodion, a novel spiro-compound from the ascomycete Chaetomium subspirale
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| 024 | 7 | 0 | |a 10.1515/BC.2004.108 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/BC.2004.108 | ||
| 245 | 0 | 0 | |a Inhibition of inducible TNF-α expression by oxaspirodion, a novel spiro-compound from the ascomycete Chaetomium subspirale |h [Elektronische Daten] |c [Jan Rether, Gerhard Erkel, Timm Anke, Olov Sterner] |
| 520 | 3 | |a In a search for compounds inhibiting the inducible TNF-αa promoter activity in T cells, a new spiro-compound, designated oxaspirodion, was isolated from fermentations of the ascomycete Chaetomium subspirale. Oxaspirodion inhibited TNF-α promoter-driven luciferase reporter gene expression with an IC50 value of 2.5 µg/ml (10 µM) in TPA/ionomycin-stimulated Jurkat T cells. Studies on the mode of action of the compound revealed that the inhibition of the TNF-α promoter activity is caused by an inhibition of the phosphorylation of the ERK1/2 kinases. In addition, oxaspirodion inhibited the activation of the transcription factor NF-κB, which is involved in the inducible expression of many proinflammatory genes. | |
| 540 | |a © Walter de Gruyter | ||
| 690 | 7 | |a Biochemistry |2 nationallicence | |
| 690 | 7 | |a Molecular biology |2 nationallicence | |
| 690 | 7 | |a Cellular biology |2 nationallicence | |
| 690 | 7 | |a ERK |2 nationallicence | |
| 690 | 7 | |a NF-κB |2 nationallicence | |
| 690 | 7 | |a oxaspirodion |2 nationallicence | |
| 690 | 7 | |a TNF-α synthesis |2 nationallicence | |
| 700 | 1 | |a Rether |D Jan |u Institut für Biotechnologie und Wirkstoff-Forschung e.V. (IBWF), Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern Germany |4 aut | |
| 700 | 1 | |a Erkel |D Gerhard |u Institut für Biotechnologie und Wirkstoff-Forschung e.V. (IBWF), Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern Germany |4 aut | |
| 700 | 1 | |a Anke |D Timm |u Institut für Biotechnologie und Wirkstoff-Forschung e.V. (IBWF), Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern Germany |4 aut | |
| 700 | 1 | |a Sterner |D Olov |u Division of Organic Chemistry 2, Chemical Center, University of Lund, S-22100 Lund, Sweden |4 aut | |
| 773 | 0 | |t Biological Chemistry |d Walter de Gruyter |g 385/9(2004-09-01), 829-834 |x 1431-6730 |q 385:9<829 |1 2004 |2 385 |o bchm | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/BC.2004.108 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/BC.2004.108 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rether |D Jan |u Institut für Biotechnologie und Wirkstoff-Forschung e.V. (IBWF), Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Erkel |D Gerhard |u Institut für Biotechnologie und Wirkstoff-Forschung e.V. (IBWF), Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Anke |D Timm |u Institut für Biotechnologie und Wirkstoff-Forschung e.V. (IBWF), Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sterner |D Olov |u Division of Organic Chemistry 2, Chemical Center, University of Lund, S-22100 Lund, Sweden |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Biological Chemistry |d Walter de Gruyter |g 385/9(2004-09-01), 829-834 |x 1431-6730 |q 385:9<829 |1 2004 |2 385 |o bchm | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
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| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||