Comparison of three commercial assays for the measurement of 17α-hydroxyprogesterone (17α-OHPR): limitations of the quality control system
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| 024 | 7 | 0 | |a 10.1515/CCLM.2004.078 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.078 | ||
| 245 | 0 | 0 | |a Comparison of three commercial assays for the measurement of 17α-hydroxyprogesterone (17α-OHPR): limitations of the quality control system |h [Elektronische Daten] |c [Ursula Meier, Claudia Schnabel, Dagmar Kunz, Reinhard Driesch, Axel M. Gressner] |
| 520 | 3 | |a The measurement of 17α-hydroxyprogesterone (17α-OHPR) is of value for the diagnosis and management of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. In the central laboratory from 2000 to 2002, we observed, using the assay from the manufacturer DSL, an elevation of the moving average of 17α-OHPR concentrations and a number of adrenocorticotropic hormone (ACTH) stimulation tests despite the lack of any changes to the internal and external quality control, of which the criteria were continuously fulfilled. We studied a population of n=49 patients for the measurement of 17α-OHPR, with and without extraction, to evaluate the quality of different commercially available radioimmunoassays. The internal and external quality controls were successful in determining 17α-OHPR. An excellent measurement and correlation of 17α-OHPR was expressed with the assay from the manufacturer IBL without extraction and from the manufacturer DSL with extraction. The quantitative determination of 17α-OHPR requires adequate specificity and accuracy of the 17α-OHPR radioimmunoassays. The results show that internal and external quality control systems are not sufficient to resolve analytical problems described in this study. | |
| 540 | |a Copyright © 2004 by Walter de Gruyter GmbH & Co. KG | ||
| 690 | 7 | |a Medical equipment & techniques |2 nationallicence | |
| 690 | 7 | |a Medical diagnosis |2 nationallicence | |
| 690 | 7 | |a Diseases & disorders |2 nationallicence | |
| 700 | 1 | |a Meier |D Ursula |4 aut | |
| 700 | 1 | |a Schnabel |D Claudia |4 aut | |
| 700 | 1 | |a Kunz |D Dagmar |4 aut | |
| 700 | 1 | |a Driesch |D Reinhard |4 aut | |
| 700 | 1 | |a Gressner |D Axel M. |4 aut | |
| 773 | 0 | |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 42/4(2004-04-05), 450-454 |x 1434-6621 |q 42:4<450 |1 2004 |2 42 |o cclm | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/CCLM.2004.078 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/CCLM.2004.078 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Meier |D Ursula |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Schnabel |D Claudia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kunz |D Dagmar |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Driesch |D Reinhard |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gressner |D Axel M. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 42/4(2004-04-05), 450-454 |x 1434-6621 |q 42:4<450 |1 2004 |2 42 |o cclm | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||