caa a22 4500 378890581 CHVBK 20180305123453.0 cr unu---uuuuu 161128e20040405xx s 000 0 eng 10.1515/CCLM.2004.074 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.074 A different approach to analyzing age-related HbA1c values in non-diabetic subjects [Elektronische Daten] [Sandrine Vallée Polneau, Virginie Lasserre, Michèle Fonfrède, Jacques Delattre, Simone Bénazeth] Using appropriate statistical tests and taking into account the analytical performance of hemoglobin A1c (HbA1c) measurements, is it useful to establish HbA1c age-related values in non-diabetic subjects? Non-diabetic subjects (n=135, 72 women and 63 men) from the neuromuscular department of the Pitié-Salpétrière Hospital (Paris) were involved in our study. Subjects were divided into two groups related to age: 51 patients under 50 years old and 84 subjects aged 50 years or more. Fasting plasma glucose and HbA1c measurements were respectively performed by enzymatic assay using the hexokinase method and high-performance liquid chromatography based on the ion exchange methodology with high precision. We first checked the normality of HbA1c distribution using the Kolmogorov-Smirnov test. Then we compared mean HbA1c in the two age subgroups using the Student's t test. Mean HbA1c was significantly (p<0.0001) higher in the subgroup aged 50 years or more (mean HbA1c=5.2%) than in younger subjects (mean HbA1c=5.0%). Then plots were drawn to check the relationship between HbA1c and age. Under the hypothesis of linearity, determination coefficients (R2) were calculated. However, considering their low values, this hypothesis must be rejected and other factors than age must be retained to explain HbA1c variability. Copyright (c) 2004 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Polneau Sandrine Vallée aut Lasserre Virginie aut Fonfrède Michèle aut Delattre Jacques aut Bénazeth Simone aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/4(2004-04-05), 423-428 1434-6621 42:4<423 2004 42 cclm https://doi.org/10.1515/CCLM.2004.074 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2004.074 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Polneau Sandrine Vallée aut NATIONALLICENCE 700 1- Lasserre Virginie aut NATIONALLICENCE 700 1- Fonfrède Michèle aut NATIONALLICENCE 700 1- Delattre Jacques aut NATIONALLICENCE 700 1- Bénazeth Simone aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/4(2004-04-05), 423-428 1434-6621 42:4<423 2004 42 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter