caa a22 4500 378890603 CHVBK 20180305123453.0 cr unu---uuuuu 161128e20040405xx s 000 0 eng 10.1515/CCLM.2004.069 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.069 Prohepcidin accumulates in renal insufficiency [Elektronische Daten] [Youri E. C. Taes, Birgitte Wuyts, Johan R. Boelaert, An S. De Vriese, Joris R. Delanghe] Background: The understanding of iron metabolism has increased substantially during the last decade. Several new transporters and iron regulating molecules have been described. Hepcidin, a small hepatic peptide has recently been proposed as a central mediator of dietary iron absorption. We have investigated the relationship between prohepcidin, the prohormone of hepcidin, and renal function and iron status. Methods: Forty six patients, referred for 51Cr-EDTA clearance were included in this study. Renal function was assessed by determination of serum creatinine, creatinine clearance, serum cystatin C and serum β-trace protein. Iron status was evaluated by determination of serum iron, transferrin, transferrin saturation and serum ferritin. All determinations were performed using commercial reagents (Roche Diagnostics, Dade Behring). Serum prohepcidin was determined using an ELISA kit. Results: Serum prohepcidin was found to correlate with 51Cr-EDTA clearance (r=−0.44; p=0.005), creatinine clearance, serum creatinine, β-trace protein and cystatin C. No significant relationship was observed between serum prohepcidin concentrations and red cell count, hemoglobin concentration or hematocrit. No significant correlation was found in this population between prohepcidin concentrations and iron status. Conclusion: Increased serum prohepcidin concentrations were observed with declining kidney function. We observed no relationship between red cell indices or iron status and serum prohepcidin concentrations. Copyright © 2004 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Taes Youri E. C. aut Wuyts Birgitte aut Boelaert Johan R. aut Vriese An S. De aut Delanghe Joris R. aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/4(2004-04-05), 387-389 1434-6621 42:4<387 2004 42 cclm https://doi.org/10.1515/CCLM.2004.069 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2004.069 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Taes Youri E. C. aut NATIONALLICENCE 700 1- Wuyts Birgitte aut NATIONALLICENCE 700 1- Boelaert Johan R. aut NATIONALLICENCE 700 1- Vriese An S. De aut NATIONALLICENCE 700 1- Delanghe Joris R. aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/4(2004-04-05), 387-389 1434-6621 42:4<387 2004 42 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter