Reference change values and power functions
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| 024 | 7 | 0 | |a 10.1515/CCLM.2004.073 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.073 | ||
| 245 | 0 | 0 | |a Reference change values and power functions |h [Elektronische Daten] |c [Natàlia Iglesias Canadell, Per Hyltoft Petersen, Esther Jensen, Carmen Ricós, Per E. Jørgensen] |
| 520 | 3 | |a Repeated samplings and measurements in the monitoring ofpatients to look for changes are common clinical problems. The "reference change value”, calculated as zP×[2×(CVI 2 + CVA 2)]1/2, where zP is the z-statistic and CVI and CVA are within-subject and analytical coefficients of variation, respectively, has been used to detect whether a measured difference between measurements is statistically significant. However, a reference change value only detects the probability of false-positives (type I error), and for this reason, a model to calculate the risk ofmissing significant changes in serial results from individuals (probability off alse-negatives) is investigated in this work by means of power functions. Therefore, when an analyte is being monitored in a patient, power functions estimate the probability of detecting a defined real change by measuring the difference. Thus, when a measured difference is the same as the calculated reference change value, then it will be detected in only 50% of situations. | |
| 540 | |a Copyright © 2004 by Walter de Gruyter GmbH & Co. KG | ||
| 690 | 7 | |a Medical equipment & techniques |2 nationallicence | |
| 690 | 7 | |a Medical diagnosis |2 nationallicence | |
| 690 | 7 | |a Diseases & disorders |2 nationallicence | |
| 700 | 1 | |a Canadell |D Natàlia Iglesias |4 aut | |
| 700 | 1 | |a Petersen |D Per Hyltoft |4 aut | |
| 700 | 1 | |a Jensen |D Esther |4 aut | |
| 700 | 1 | |a Ricós |D Carmen |4 aut | |
| 700 | 1 | |a Jørgensen |D Per E. |4 aut | |
| 773 | 0 | |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 42/4(2004-04-05), 415-422 |x 1434-6621 |q 42:4<415 |1 2004 |2 42 |o cclm | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/CCLM.2004.073 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/CCLM.2004.073 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Canadell |D Natàlia Iglesias |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Petersen |D Per Hyltoft |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Jensen |D Esther |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ricós |D Carmen |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Jørgensen |D Per E. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 42/4(2004-04-05), 415-422 |x 1434-6621 |q 42:4<415 |1 2004 |2 42 |o cclm | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||