caa a22 4500 378891863 CHVBK 20180305123456.0 cr unu---uuuuu 161128e20040315xx s 000 0 eng 10.1515/HF.2004.028 doi (NATIONALLICENCE)gruyter-10.1515/HF.2004.028 Antifungal activity of constituents from the heartwood of Gmelina arborea: Part 1. Sensitive antifungal assay against Basidiomycetes [Elektronische Daten] [F. Kawamura, S. Ohara, A. Nishida] Antifungal activity of constituents from the heartwood of the Malaysian Gmelina arborea against Trametes versicolor and Fomitopsis palustris was investigated. A sensitive bioassay system for antifungal activity against basidiomycetes was developed which uses a medium in which homogenized hyphae were dispersed. Ethyl acetate- solubles from the heartwood showed the highest activity against both fungi, although the activity against F. palustris was quite weak. Spots exhibiting antifungal activity against T. versicolor were specified by autobiography of ethyl acetate-solubles, and five constituents were isolated and identified as (+)-7′-O-ethyl arboreol, (+)-paulownin, (+)-gmelinol, (+)-epieudesmin and (−)-β-sitosterol. The four lignans showed antifungal activity, whereas β-sitosterol did not. From the comparison of antifungal activity, it was concluded that the piperonyl nucleus contributed to the activity of lignans. Of the four lignans isolated, gmelinol appeared to be an important antifungal constituent, since it was rich in the heartwood of G. arborea. Furthermore, the synergism by coexistence of these five compounds was confirmed. Copyright © 2004 by Walter de Gruyter GmbH & Co. KG Timber & wood processing nationallicence Biotechnology nationallicence Materials science nationallicence Kawamura F. aut Ohara S. aut Nishida A. aut Holzforschung Walter de Gruyter 58/2(2004-03-15), 189-192 0018-3830 58:2<189 2004 58 hfsg https://doi.org/10.1515/HF.2004.028 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/HF.2004.028 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kawamura F. aut NATIONALLICENCE 700 1- Ohara S. aut NATIONALLICENCE 700 1- Nishida A. aut NATIONALLICENCE 773 0- Holzforschung Walter de Gruyter 58/2(2004-03-15), 189-192 0018-3830 58:2<189 2004 58 hfsg CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter